U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    bamC outer membrane protein assembly factor BamC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946954, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    bamC
    Official Full Name
    outer membrane protein assembly factor BamC
    Primary source
    ECOCYC:EG10658
    Locus tag
    b2477
    See related
    ASAP:ABE-0008161
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dapX; ECK2473; nlpB
    Summary
    RpoE regulon. [More information is available at EcoGene: EG10658]. NlpB is a putative lipoprotein as determined by sequence analysis. [More information is available at EcoCyc: EG10658].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2597831..2598865, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YpfJ Neighboring gene phosphoribosylaminoimidazole-succinocarboxamide synthase Neighboring gene 4-hydroxy-tetrahydrodipicolinate synthase Neighboring gene putative transcriptional regulator GcvR Neighboring gene thiol peroxidase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Dynamic association of BAM complex modules includes surface exposure of the lipoprotein BamC. Webb CT, et al. J Mol Biol, 2012 Sep 28. PMID 22683355, Free PMC Article
    2. Crystallographic analysis of the C-terminal domain of the Escherichia coli lipoprotein BamC. Kim KH, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Nov 1. PMID 22102230, Free PMC Article
    3. Structure of the BamC two-domain protein obtained by Rosetta with a limited NMR data set. Warner LR, et al. J Mol Biol, 2011 Aug 5. PMID 21624375, Free PMC Article
    4. Secondary structure and (1)H, (13)C and (15)N backbone resonance assignments of BamC, a component of the outer membrane protein assembly machinery in Escherichia coli. Knowles TJ, et al. Biomol NMR Assign, 2009 Dec. PMID 19888691
    5. Studying assembly of the BAM complex in native membranes by cellular solid-state NMR spectroscopy. Pinto C, et al. J Struct Biol, 2019 Apr 1. PMID 29197585

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate structural variations in the central domain, outer membrane protein BamA (BamA), as well as in the lipoprotein outer membrane protein assembly factor BamC (BamC).
      Title: Studying assembly of the BAM complex in native membranes by cellular solid-state NMR spectroscopy.
    2. crystal structure of the C-terminal domain of E. coli BamC (BamC(C): Ala224-Ser343) refined to 1.5 A resolution in space group H3 is reported. BamC(C) consists of a six-stranded antiparallel beta-sheet, three alpha-helices and one 3(10)-helix
      Title: Crystallographic analysis of the C-terminal domain of the Escherichia coli lipoprotein BamC.
    3. The unstructured N terminus of BamC interacts with the proposed substrate-binding pocket of BamD, suggesting that this region of BamC may play a regulatory role in outer membrane protein biogenesis.
      Title: Crystal structure of β-barrel assembly machinery BamCD protein complex.
    4. The Rosetta calculations showed that BamC forms two well-defined domains connected by an ~18-residue linker, where the relative orientation of the domains was not defined.
      Title: Structure of the BamC two-domain protein obtained by Rosetta with a limited NMR data set.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Gram-negative-bacterium-type cell outer membrane assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Gram-negative-bacterium-type cell outer membrane assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Gram-negative-bacterium-type cell outer membrane assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein insertion into membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein insertion into membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Bam protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Bam protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    outer membrane protein assembly factor BamC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2597831..2598865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416972.4 outer membrane protein assembly factor BamC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416972.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      C3T0D2
      Conserved Domains (1) summary
      PRK11679
      Location:1 → 344
      PRK11679; outer membrane protein assembly factor BamC
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.