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    sseA 3-mercaptopyruvate sulfurtransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946993, updated on 17-Dec-2024

    Summary

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    Official Symbol
    sseA
    Official Full Name
    3-mercaptopyruvate sulfurtransferase
    Primary source
    ECOCYC:EG11600
    Locus tag
    b2521
    See related
    ASAP:ABE-0008299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2517; mstA
    Summary
    The sseA gene encodes a 3-mercaptopyruvate:cyanide sulfurtransferase (MST), a rhodanese-like enzyme that, in contrast to rhodanese, uses 3-mercaptopyruvate as the preferred sulfur donor . [More information is available at EcoCyc: EG11600].
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    Genomic context

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    Sequence:
    NC_000913.3 (2652494..2653339)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidoglycan glycosyltransferase PbpC Neighboring gene alpha2-macroglobulin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene putative toxic protein TimP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of H(2)S-mediated protection against oxidative stress in Escherichia coli. Mironov A, et al. Proc Natl Acad Sci U S A, 2017 Jun 6. PMID 28533366, Free PMC Article
    2. H2S: a universal defense against antibiotics in bacteria. Shatalin K, et al. Science, 2011 Nov 18. PMID 22096201
    3. The "rhodanese" fold and catalytic mechanism of 3-mercaptopyruvate sulfurtransferases: crystal structure of SseA from Escherichia coli. Spallarossa A, et al. J Mol Biol, 2004 Jan 9. PMID 14672665
    4. SseA, a 3-mercaptopyruvate sulfurtransferase from Escherichia coli: crystallization and preliminary crystallographic data. Spallarossa A, et al. Acta Crystallogr D Biol Crystallogr, 2003 Jan. PMID 12499560
    5. Properties of the Escherichia coli rhodanese-like protein SseA: contribution of the active-site residue Ser240 to sulfur donor recognition. Colnaghi R, et al. FEBS Lett, 2001 Jul 6. PMID 11445076

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-mercaptopyruvate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-mercaptopyruvate sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-mercaptopyruvate sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiosulfate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiosulfate sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiosulfate sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA protection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-mercaptopyruvate sulfurtransferase
    NP_417016.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2652494..2653339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417016.4 3-mercaptopyruvate sulfurtransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417016.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MCH6
      Conserved Domains (1) summary
      PRK11493
      Location:1 → 281
      sseA; 3-mercaptopyruvate sulfurtransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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