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    mltF membrane-bound lytic murein transglycosylase F [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947028, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mltF
    Official Full Name
    membrane-bound lytic murein transglycosylase F
    Primary source
    ECOCYC:EG11373
    Locus tag
    b2558
    See related
    ASAP:ABE-0008417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2556; yfhD
    Summary
    The N-terminus (22-273) is homologous to ABC-type periplasmic binding proteins; the C-terminus (294-387) encodes the MltF function. [More information is available at EcoGene: EG11373]. MltF is a membrane-bound lytic transglycosylase responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan . [More information is available at EcoCyc: EG11373].
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    Genomic context

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    Sequence:
    NC_000913.3 (2695801..2697357)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phosphoribosylformylglycinamide synthetase Neighboring gene tRNA adenosine(34) deaminase Neighboring gene phosphatidylglycerophosphatase C Neighboring gene putative DNA-binding transcriptional regulator YfhH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification, crystallization and preliminary X-ray diffraction analysis of the lytic transglycosylase MltF from Escherichia coli. Madoori PK, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 May 1. PMID 20445253, Free PMC Article
    2. The C-terminal domain of Escherichia coli YfhD functions as a lytic transglycosylase. Scheurwater EM, et al. J Biol Chem, 2008 Mar 28. PMID 18234673, Free PMC Article
    3. Formylglycinamide ribonucleotide synthetase from Escherichia coli: cloning, sequencing, overproduction, isolation, and characterization. Schendel FJ, et al. Biochemistry, 1989 Mar 21. PMID 2659070
    4. Analysis of an Escherichia coli mutant strain resistant to the cell-killing function encoded by the gef gene family. Poulsen LK, et al. Mol Microbiol, 1992 Apr. PMID 1602968
    5. Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. Lee M, et al. J Am Chem Soc, 2013 Mar 6. PMID 23421439, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lytic transglycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lytic transglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lytic transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall macromolecule catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidoglycan catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cell outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane-bound lytic murein transglycosylase F

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2695801..2697357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417053.2 membrane-bound lytic murein transglycosylase F [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417053.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M6B9
      Conserved Domains (1) summary
      PRK10859
      Location:1 → 483
      PRK10859; membrane-bound lytic murein transglycosylase MltF
    Nucleotide Protein
    Heading Accession and Version

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