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    era 30S ribosomal subunit maturation GTPase Era [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947036, updated on 3-Dec-2024

    Summary

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    Official Symbol
    era
    Official Full Name
    30S ribosomal subunit maturation GTPase Era
    Primary source
    ECOCYC:EG10270
    Locus tag
    b2566
    See related
    ASAP:ABE-0008440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2564; rbaA; sdgE
    Summary
    era was demonstrated to be an essential gene (Takiff, 1992), consistent with the results of Baba (2006). [More information is available at EcoGene: EG10270]. The era gene is essential for viability . [More information is available at EcoCyc: EG10270].
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    Genomic context

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    Sequence:
    NC_000913.3 (2702481..2703386, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene holo-[acyl-carrier-protein] synthase Neighboring gene pyridoxine 5'-phosphate synthase Neighboring gene recombination mediator protein RecO Neighboring gene RNase III Neighboring gene signal peptidase I Neighboring gene 30S ribosomal subunit biogenesis factor LepA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cold-sensitive conditional mutations in Era, an essential Escherichia coli GTPase, isolated by localized random polymerase chain reaction mutagenesis. Lerner CG, et al. FEMS Microbiol Lett, 1995 Mar 1. PMID 7729673
    2. ATPase and GTPase activities copurifying with GTP-binding proteins in E. coli. Sayed A, et al. J Mol Microbiol Biotechnol, 2000 Jul. PMID 10937433
    3. Analysis of guanine nucleotide binding and exchange kinetics of the Escherichia coli GTPase Era. Sullivan SM, et al. J Bacteriol, 2000 Jun. PMID 10852878, Free PMC Article
    4. The widely conserved Era G-protein contains an RNA-binding domain required for Era function in vivo. Johnstone BH, et al. Mol Microbiol, 1999 Sep. PMID 10510227
    5. Purification, characterization and crystallization of ERA, an essential GTPase from Escherichia coli. Chen X, et al. FEBS Lett, 1999 Feb 26. PMID 10094501

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overproduction of a Dominant Mutant of the Conserved Era GTPase Inhibits Cell Division in Escherichia coli.
      Title: Overproduction of a Dominant Mutant of the Conserved Era GTPase Inhibits Cell Division in Escherichia coli.
    2. Data indicate Era's role in ribosome assembly and suggests new roles in maintaining ribosome homeostasis.
      Title: Role of Era in assembly and homeostasis of the ribosomal small subunit.
    3. overexpression of the conserved GTPase Era in Escherichia coli partially suppresses the growth defect of a DeltaybeY strain while improving 16S rRNA processing and 70S ribosome assembly
      Title: Elevated Levels of Era GTPase Improve Growth, 16S rRNA Processing, and 70S Ribosome Assembly of Escherichia coli Lacking Highly Conserved Multifunctional YbeY Endoribonuclease.
    4. Structure and fuction of ERA in cell cycle control is reviewed.
      Title: Structural insights into cell cycle control by essential GTPase Era.
    5. Data show that Era ameliorated the growth and polysome defects of the delta yjeQ strain.
      Title: Genetic interaction screens with ordered overexpression and deletion clone sets implicate the Escherichia coli GTPase YjeQ in late ribosome biogenesis.
    6. The results indicated that YggG expression is significantly increased in response to stress caused by the Era-1 mutant protein in E. coli, thus promoting the growth of E. coli.
      Title: Up-regulation of yggG promotes the survival of Escherichia coli cells containing Era-1 mutant protein.
    7. N-terminus verified by Edman degradation on mature peptide
      Title: Expression and characterization of RNase III and Era proteins. Products of the rnc operon of Escherichia coli.
    8. Era and RbfA have an overlapping function that is essential for ribosome biogenesis.
      Title: Era and RbfA have overlapping function in ribosome biogenesis in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine tetraphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal small subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small ribosomal subunit rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small ribosomal subunit rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ribosomal small subunit assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ribosomal small subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ribosomal small subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ribosomal small subunit biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    colocalizes_with cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    30S ribosomal subunit maturation GTPase Era
    NP_417061.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2702481..2703386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417061.1 30S ribosomal subunit maturation GTPase Era [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417061.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L9ICH1, A0A7A6MTI2
      Conserved Domains (1) summary
      PRK00089
      Location:4 → 297
      era; GTPase Era; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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