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    srlD sorbitol-6-phosphate 2-dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948937, updated on 3-Dec-2024

    Summary

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    Official Symbol
    srlD
    Official Full Name
    sorbitol-6-phosphate 2-dehydrogenase
    Primary source
    ECOCYC:EG10971
    Locus tag
    b2705
    See related
    ASAP:ABE-0008896
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2700; gutD
    Summary
    False positive lipoprotein prediction, unprocessed, verified amino terminus. [More information is available at EcoGene: EG10971].
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    Genomic context

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    Sequence:
    NC_000913.3 (2827737..2828516)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene sorbitol-specific PTS enzyme IIC2 component Neighboring gene sorbitol-specific PTS enzyme IIBC1 component Neighboring gene sorbitol-specific PTS enzyme IIA component Neighboring gene DNA-binding transcriptional activator GutM Neighboring gene DNA-binding transcriptional repressor SrlR Neighboring gene D-arabinose 5-phosphate isomerase GutQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preliminary studies on the inhibition of D-sorbitol-6-phosphate 2-dehydrogenase from Escherichia coli with substrate analogues. Roux C, et al. J Enzyme Inhib Med Chem, 2006 Apr. PMID 16791965
    2. Mutations affecting transport of the hexitols D-mannitol, D-glucitol, and galactitol in Escherichia coli K-12: isolation and mapping. Lengeler J. J Bacteriol, 1975 Oct. PMID 1100602, Free PMC Article
    3. Purification and properties of D-mannitol-1-phosphate dehydrogenase and D-glucitol-6-phosphate dehydrogenase from Escherichia coli. Novotny MJ, et al. J Bacteriol, 1984 Sep. PMID 6384188, Free PMC Article
    4. Physical mapping of the srl recA region of Escherichia coli: analysis of Tn10 generated insertions and deletions. Willis DK, et al. Mol Gen Genet, 1981. PMID 6278241
    5. Genetic analysis of the Escherichia coli K-12 srl region. McEntee K. J Bacteriol, 1977 Dec. PMID 336611, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Purification and properties of D-mannitol-1-phosphate dehydrogenase and D-glucitol-6-phosphate dehydrogenase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sorbitol-6-phosphate 2-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sorbitol-6-phosphate 2-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein homotetramerization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sorbitol catabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in sorbitol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sorbitol-6-phosphate 2-dehydrogenase
    NP_417185.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2827737..2828516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417185.1 sorbitol-6-phosphate 2-dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417185.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      B1A9T9
      Conserved Domains (1) summary
      PRK12384
      Location:1 → 259
      PRK12384; sorbitol-6-phosphate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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