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    ftsB cell division protein FtsB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946033, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ftsB
    Official Full Name
    cell division protein FtsB
    Primary source
    ECOCYC:G7424
    Locus tag
    b2748
    See related
    ASAP:ABE-0009019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2743; ygbQ
    Summary
    ftsB is an essential gene. [More information is available at EcoGene: EG13111]. FtsB is an essential cell division protein which localizes to the cell division site. [More information is available at EcoCyc: G7424].
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    Genomic context

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    Sequence:
    NC_000913.3 (2872509..2872820, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA pseudouridine(13) synthase Neighboring gene 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Neighboring gene 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Neighboring gene DUF3561 domain-containing inner membrane protein YgbE Neighboring gene adenylyl-sulfate kinase Neighboring gene sulfate adenylyltransferase subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural organization of FtsB, a transmembrane protein of the bacterial divisome. LaPointe LM, et al. Biochemistry, 2013 Apr 16. PMID 23520975, Free PMC Article
    2. Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB. Kureisaite-Ciziene D, et al. mBio, 2018 Sep 11. PMID 30206170, Free PMC Article
    3. The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions. Condon SGF, et al. J Biol Chem, 2018 Feb 2. PMID 29233891, Free PMC Article
    4. Bacterial cytokinesis: From Z ring to divisome. Lutkenhaus J, et al. Cytoskeleton (Hoboken), 2012 Oct. PMID 22888013, Free PMC Article
    5. The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation. Kong WP, et al. J Biol Chem, 2022 Aug. PMID 35798142, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
      Title: The structural dynamics of full-length divisome transmembrane proteins FtsQ, FtsB, and FtsL in FtsQBL complex formation.
    2. The authors discovered that FtsBLQ inhibits the glycosyltransferase activity of PBP1b and that this inhibition was antagonized by the PBP1b activators FtsN and LpoB.
      Title: Regulation of the Peptidoglycan Polymerase Activity of PBP1b by Antagonist Actions of the Core Divisome Proteins FtsBLQ and FtsN.
    3. Crystal structure of FtsB bound to the beta domain of FtsQ shows that only residues 64 to 87 of FtsB interact with FtsQ.
      Title: Structural Analysis of the Interaction between the Bacterial Cell Division Proteins FtsQ and FtsB.
    4. The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions.
      Title: The FtsLB subcomplex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions.
    5. results support a model in which FtsL, along with its partners FtsB and FtsQ, function as part of a sensing mechanism that promotes the onset of cell wall remodeling processes.
      Title: A role for the FtsQLB complex in cytokinetic ring activation revealed by an ftsL allele that accelerates division.
    6. A structural model was developed for the periplasmic part of the FtsB/FtsL/FtsQ complex.
      Title: A model for the Escherichia coli FtsB/FtsL/FtsQ cell division complex.
    7. The authors demonstrate that the leucine zipper-like (LZ) motifs, located in the periplasmic domain of FtsL and FtsB, are required for an optimal interaction between these two essential proteins.
      Title: Role of leucine zipper motifs in association of the Escherichia coli cell division proteins FtsL and FtsB.
    8. Study find that, as with FtsB, the C terminus of FtsL is required for the interaction of FtsQ with the FtsB/FtsL subcomplex while the cytoplasmic domain of FtsL is involved in recruitment of the downstream division proteins.
      Title: Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex.
    9. The N-terminal half of FtsB is necessary for interaction with FtsL and sufficient, when in complex with FtsL, for recruitment of downstream division proteins, while a portion of the FtsB C terminus is necessary for interaction with FtsQ.
      Title: Divisome under construction: distinct domains of the small membrane protein FtsB are necessary for interaction with multiple cell division proteins.
    10. FtsB is associated in a hierarchical set of protein complexes and its assembly can occur independently of 'upstream' proteins.
      Title: Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FtsZ-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in FtsZ-dependent cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within FtsZ-dependent cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in FtsZ-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in division septum assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FtsBL complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of FtsQBL complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell division site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell division site NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cell septum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of divisome complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of divisome complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division protein FtsB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2872509..2872820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417228.1 cell division protein FtsB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417228.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376TUJ3
      Conserved Domains (1) summary
      PRK00888
      Location:16 → 103
      ftsB; cell division protein FtsB; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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