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    speA biosynthetic arginine decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947432, updated on 3-Dec-2024

    Summary

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    Official Symbol
    speA
    Official Full Name
    biosynthetic arginine decarboxylase
    Primary source
    ECOCYC:EG10959
    Locus tag
    b2938
    See related
    ASAP:ABE-0009634
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2933
    Summary
    Biosynthetic arginine decarboxylase (SpeA) carries out the first step in putrescine biosynthesis, converting L-arginine to agmatine. [More information is available at EcoCyc: EG10959].
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    Genomic context

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    Sequence:
    NC_000913.3 (3083935..3085911, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene metalloprotease LoiP Neighboring gene agmatinase Neighboring gene acid stress response protein YqgB Neighboring gene protein YqgG Neighboring gene protein YqgC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthetic arginine decarboxylase in Escherichia coli is synthesized as a precursor and located in the cell envelope. Buch JK, et al. J Bacteriol, 1985 Aug. PMID 3894328, Free PMC Article
    2. Partial separation of two pools of arginine in Escherichia coli; preferential use of exogenous rather than endogenous arginine for the biosynthesis of 1,4-diaminobutane. Tabor H, et al. J Biol Chem, 1969 Dec 10. PMID 4901370
    3. Biosynthetic arginine decarboxylase from Escherichia coli. Subunit interactions and the role of magnesium ion. Wu WH, et al. J Biol Chem, 1973 Mar 10. PMID 4571774
    4. Biosynthetic arginine decarboxylase from Escherichia coli. Purification and properties. Wu WH, et al. J Biol Chem, 1973 Mar 10. PMID 4571773
    5. Post-translational and transcriptional regulation of polyamine biosynthesis in Escherichia coli. Panagiotidis CA, et al. Int J Biochem, 1994 Aug. PMID 8088419

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rationally Engineering pH Adaptation of Acid-Induced Arginine Decarboxylase from Escherichia coli to Alkaline Environments to Efficiently Biosynthesize Putrescine.
      Title: Rationally Engineering pH Adaptation of Acid-Induced Arginine Decarboxylase from Escherichia coli to Alkaline Environments to Efficiently Biosynthesize Putrescine.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables arginine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arginine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arginine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within arginine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arginine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within putrescine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in putrescine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in putrescine biosynthetic process from arginine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within putrescine biosynthetic process from arginine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    biosynthetic arginine decarboxylase
    NP_417413.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3083935..3085911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417413.1 biosynthetic arginine decarboxylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417413.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6ZU92
      Conserved Domains (1) summary
      COG1166
      Location:6 → 658
      SpeA; Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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