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    hybF hydrogenase maturation protein HybF [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948004, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hybF
    Official Full Name
    hydrogenase maturation protein HybF
    Primary source
    ECOCYC:EG11804
    Locus tag
    b2991
    See related
    ASAP:ABE-0009818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2985
    Summary
    Paralogous to hypA, which may have a regulatory role. [More information is available at EcoGene: EG11804]. The HybF protein is required for maturation of hydrogenase isozymes 1 and 2 and probably plays a role in the nickel cofactor insertion step . [More information is available at EcoCyc: EG11804].
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    Genomic context

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    Sequence:
    NC_000913.3 (3139977..3140318, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene disulfide reductase/organic hydroperoxide reductase Neighboring gene hydrogenase maturation factor HybG Neighboring gene hydrogenase 2-specific chaperone Neighboring gene hydrogenase 2 maturation protease Neighboring gene hydrogenase 2 large subunit Neighboring gene hydrogenase 2 membrane subunit Neighboring gene hydrogenase 2 iron-sulfur protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HybF, a zinc-containing protein involved in NiFe hydrogenase maturation. Blokesch M, et al. J Bacteriol, 2004 May. PMID 15090500, Free PMC Article
    2. Maturation of [NiFe]-hydrogenases in Escherichia coli. Forzi L, et al. Biometals, 2007 Jun. PMID 17216401
    3. Reassignment of the gene encoding the Escherichia coli hydrogenase 2 small subunit--identification of a soluble precursor of the small subunit in a hypB mutant. Sargent F, et al. Eur J Biochem, 1998 Aug 1. PMID 9738917
    4. Cloning, sequencing, and mutational analysis of the hyb operon encoding Escherichia coli hydrogenase 2. Menon NK, et al. J Bacteriol, 1994 Jul. PMID 8021226, Free PMC Article
    5. Network of hydrogenase maturation in Escherichia coli: role of accessory proteins HypA and HybF. Hube M, et al. J Bacteriol, 2002 Jul. PMID 12081959, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallochaperone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nickel cation binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nickel cation binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nickel cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydrogenase maturation protein HybF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3139977..3140318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417465.1 hydrogenase maturation protein HybF [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417465.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N0IM80
      Conserved Domains (1) summary
      PRK12380
      Location:1 → 113
      PRK12380; hydrogenase/urease nickel incorporation protein
    Nucleotide Protein
    Heading Accession and Version

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