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    yqhC DNA-binding transcriptional activator YqhC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947491, updated on 17-Dec-2024

    Summary

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    Official Symbol
    yqhC
    Official Full Name
    DNA-binding transcriptional activator YqhC
    Primary source
    ECOCYC:G7563
    Locus tag
    b3010
    See related
    ASAP:ABE-0009884
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3002
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    Genomic context

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    Sequence:
    NC_000913.3 (3154262..3155218, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cystathionine beta-lyase/L-cysteine desulfhydrase/alanine racemase Neighboring gene DedA family protein YghB Neighboring gene NADPH-dependent aldehyde reductase YqhD Neighboring gene methylglyoxal reductase DkgA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YqhC regulates transcription of the adjacent Escherichia coli genes yqhD and dkgA that are involved in furfural tolerance. Turner PC, et al. J Ind Microbiol Biotechnol, 2011 Mar. PMID 20676725
    2. Silencing of NADPH-dependent oxidoreductase genes (yqhD and dkgA) in furfural-resistant ethanologenic Escherichia coli. Miller EN, et al. Appl Environ Microbiol, 2009 Jul. PMID 19429550, Free PMC Article
    3. Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12. Lee C, et al. J Bacteriol, 2010 Aug. PMID 20543070, Free PMC Article
    4. The repertoire of DNA-binding transcriptional regulators in Escherichia coli K-12. Pérez-Rueda E, et al. Nucleic Acids Res, 2000 Apr 15. PMID 10734204, Free PMC Article
    5. Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea. Pérez-Rueda E, et al. Comput Biol Chem, 2004 Dec. PMID 15556475

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. yqhC is the positive regulator of the yqhD dkgA operon. Silencing yqhC increases furfural tolerance.
      Title: YqhC regulates transcription of the adjacent Escherichia coli genes yqhD and dkgA that are involved in furfural tolerance.
    2. The authors propose that YqhC is a transcriptional activator of YqhD, which acts as an aldehyde reductase with specificity for certain aldehydes, including glyoxal.
      Title: Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator YqhC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3154262..3155218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417483.2 DNA-binding transcriptional activator YqhC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417483.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0D6H8U5, A0A0E2LGH3, A0A140N7U7, A0A7I0L063, A0A7I6H4H8, B7MA73, B7MZZ7, B7ND01, B7UIR1, S1P7U9
      Conserved Domains (2) summary
      COG2207
      Location:197 → 316
      AraC; AraC-type DNA-binding domain and AraC-containing proteins [Transcription]
      pfam06719
      Location:47 → 198
      AraC_N; AraC-type transcriptional regulator N-terminus
    Nucleotide Protein
    Heading Accession and Version

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