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    mdaB NADPH:quinone oxidoreductase MdaB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947512, updated on 3-Dec-2024

    Summary

    Official Symbol
    mdaB
    Official Full Name
    NADPH:quinone oxidoreductase MdaB
    Primary source
    ECOCYC:EG12656
    Locus tag
    b3028
    See related
    ASAP:ABE-0009946
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3019; mda66
    Summary
    MdaB overexpression results in resistance to cytotoxic drugs including adriamycin, etoposide and the tumoricidal agent DMP 840. [More information is available at EcoGene: EG12656]. The MdaB quinone reductase is specific for NADPH and is most active with quinone derivatives and ferricyanide . [More information is available at EcoCyc: EG12656].
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    Genomic context

    Sequence:
    NC_000913.3 (3172530..3173111)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator QseB Neighboring gene sensor histidine kinase QseC Neighboring gene DUF2645 domain-containing inner membrane protein YgiZ Neighboring gene putative quinol monooxygenase YgiN Neighboring gene DNA topoisomerase IV subunit B

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    NADPH:quinone oxidoreductase MdaB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3172530..3173111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417500.1 NADPH:quinone oxidoreductase MdaB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417500.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1PMY3, A0A6C9FIH4, A0A7A6U6A5
      Conserved Domains (1) summary
      COG2249
      Location:3193
      MdaB; Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]