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    pitA metal phosphate:H(+) symporter PitA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948009, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pitA
    Official Full Name
    metal phosphate:H(+) symporter PitA
    Primary source
    ECOCYC:EG12230
    Locus tag
    b3493
    See related
    ASAP:ABE-0011407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3478; pit
    Summary
    The PitA phosphate transporter is a member of the Inorganic Phosphate Transporter (PiT) family. [More information is available at EcoCyc: EG12230].
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    Genomic context

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    Sequence:
    NC_000913.3 (3637642..3639141)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein YhiM Neighboring gene putative oxidoreductase YhiN Neighboring gene universal stress protein B Neighboring gene universal stress protein A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tellurite enters Escherichia coli mainly through the PitA phosphate transporter. Elías AO, et al. Microbiologyopen, 2012 Sep. PMID 23189244, Free PMC Article
    2. Phosphate transport in membrane vesicles from Escherichia coli. Konings WN, et al. Biochim Biophys Acta, 1978 Apr 4. PMID 346064
    3. A mutant of Escherichia coli auxotrophic for organic phosphates: evidence for two defects in inorganic phosphate transport. Sprague GF Jr, et al. Mol Gen Genet, 1975 Dec 30. PMID 765745
    4. Characterization of two genetically separable inorganic phosphate transport systems in Escherichia coli. Willsky GR, et al. J Bacteriol, 1980 Oct. PMID 6998957, Free PMC Article
    5. Effect of arsenate on inorganic phosphate transport in Escherichia coli. Willsky GR, et al. J Bacteriol, 1980 Oct. PMID 6998959, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors suggest that MgtS binds to and prevents Mg(2+) leakage through PitA under Mg(2+) -limiting conditions. Consistent with a detrimental role of PitA in low Mg(2+) , they also observe MgrR sRNA repression of PitA synthesis.
      Title: The small protein MgtS and small RNA MgrR modulate the PitA phosphate symporter to boost intracellular magnesium levels.
    2. Relative gene expression experiments by quantitative real-time PCR showed that actP expression is enhanced at short times of tellurite exposure, while pitA and pitB genes are induced later.
      Title: The ActP acetate transporter acts prior to the PitA phosphate carrier in tellurite uptake by Escherichia coli.
    3. Activity of PitA transcriptional fusion was maximal at high extracellular Zn and in the absence of inorganic phosphate.
      Title: Expression of the PitA phosphate/metal transporter of Escherichia coli is responsive to zinc and inorganic phosphate levels.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables arsenate ion transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables phosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables solute:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tellurite transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within arsenate ion transmembrane transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within magnesium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphate ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphate ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tellurite transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zinc ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metal phosphate:H(+) symporter PitA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3637642..3639141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417950.1 metal phosphate:H(+) symporter PitA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417950.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FVY9, A0A6N8R4M0
      Conserved Domains (1) summary
      NF033774
      Location:1 → 499
      phos_trans_PitA; inorganic phosphate transporter PitA
    Nucleotide Protein
    Heading Accession and Version

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