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    argC N-acetylglutamylphosphate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948455, updated on 17-Dec-2024

    Summary

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    Official Symbol
    argC
    Official Full Name
    N-acetylglutamylphosphate reductase
    Primary source
    ECOCYC:EG10065
    Locus tag
    b3958
    See related
    ASAP:ABE-0012964
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    Arg2; ECK3949
    Summary
    N-acetylglutamylphosphate reductase (ArgC) carries out the third step in arginine biosynthesis and its subpathway, ornithine biosynthesis. [More information is available at EcoCyc: EG10065].
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    Genomic context

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    Sequence:
    NC_000913.3 (4155001..4156005)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoenolpyruvate carboxylase Neighboring gene acetylornithine deacetylase Neighboring gene acetylglutamate kinase Neighboring gene argininosuccinate lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-Acetyl-gamma-Ilutamokinase and N-acetylglutamic gamma-semialdehyde dehydrogenase: repressible enzymes of arginine synthesis in Escherichia coli. BAICH A, et al. Biochem Biophys Res Commun, 1962 Jun 4. PMID 13863980
    2. The C-terminal end of AraC tightly binds to the rest of its domain. Harmer TL, et al. J Biol Chem, 2001 Feb 16. PMID 11104764
    3. The regulatory region of the divergent argECBH operon in Escherichia coli K-12. Piette J, et al. Nucleic Acids Res, 1982 Dec 20. PMID 6761650, Free PMC Article
    4. Promoter mapping and selection of operator mutants by using insertion of bacteriophage Mu in the argECBH divergent operon of Escherichia coli K-12. Beny G, et al. J Bacteriol, 1982 Jul. PMID 6211434, Free PMC Article
    5. Structural and biochemical characterization of the Escherichia coli argE gene product. Meinnel T, et al. J Bacteriol, 1992 Apr. PMID 1551850, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables N-acetyl-gamma-glutamyl-phosphate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetyl-gamma-glutamyl-phosphate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-arginine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylglutamylphosphate reductase
    NP_418393.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4155001..4156005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418393.1 N-acetylglutamylphosphate reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418393.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376TQB9
      Conserved Domains (1) summary
      PRK00436
      Location:1 → 333
      argC; N-acetyl-gamma-glutamyl-phosphate reductase; Validated
    Nucleotide Protein
    Heading Accession and Version

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