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    lamB maltose outer membrane channel/phage lambda receptor protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948548, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lamB
    Official Full Name
    maltose outer membrane channel/phage lambda receptor protein
    Primary source
    ECOCYC:EG10528
    Locus tag
    b4036
    See related
    ASAP:ABE-0013218
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4028; malB; malL
    Summary
    LamB also facilitates the diffusion of maltooligosaccharides, i.e maltodextrin. [More information is available at EcoGene: EG10528]. LamB is a member of the Sugar Porin (SP) family. [More information is available at EcoCyc: EG10528].
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    Genomic context

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    Sequence:
    NC_000913.3 (4247971..4249311)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene maltose ABC transporter periplasmic binding protein Neighboring gene maltose ABC transporter ATP binding subunit Neighboring gene maltose regulon periplasmic protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway. Dutzler R, et al. Structure, 1996 Feb 15. PMID 8805519
    2. Signal sequence mutations as tools for the characterization of LamB folding intermediates. Duguay AR, et al. J Bacteriol, 2002 Dec. PMID 12446642, Free PMC Article
    3. PH-induced collapse of the extracellular loops closes Escherichia coli maltoporin and allows the study of asymmetric sugar binding. Andersen C, et al. J Biol Chem, 2002 Nov 1. PMID 12185084
    4. Site-directed mutagenesis within the central constriction site of ScrY (sucroseporin): effect on ion transport and comparison of maltooligosaccharide binding to LamB of Escherichia coli. Kim BH, et al. J Membr Biol, 2002 Jun 1. PMID 12163981
    5. Site-directed mutagenesis of tyrosine 118 within the central constriction site of the LamB (maltoporin) channel of Escherichia coli. II. Effect on maltose and maltooligosaccharide binding kinetics. Orlik F, et al. Biophys J, 2002 Jul. PMID 12080122, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
      Title: LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
    2. Our data indicate that the negative regulation by LamB is widely detected in antibiotic-resistant E. coli. LamB serves as a porin to influx an antibiotic and is interacted with Odp1.
      Title: Decreased expression of LamB and Odp1 complex is crucial for antibiotic resistance in Escherichia coli.
    3. Elevated expression of LamB causes cell death when the osmoregulator OmpR is disabled.
      Title: Constitutive expression of the maltoporin LamB in the absence of OmpR damages the cell envelope.
    4. Results report the crystallization of E. coli maltoporin in a new crystal form; the crystals belonged to the trigonal R3 space group and diffracted to 1.9 A resolution.
      Title: Crystallization of Escherichia coli maltoporin in the trigonal space group R3.
    5. downregulation of LamB expression in the CTC-resistant E. coli strain and the increased antibiotic resistance in its gene-deleted strain suggested a negative regulation mechanism in E. coli in response to CTC
      Title: A novel negative regulation mechanism of bacterial outer membrane proteins in response to antibiotic resistance.
    6. Data report that cells lacking OmpR and harboring constitutively active MalT undergo premature death that involves increased expression of the outer membrane porin LamB.
      Title: A critical process controlled by MalT and OmpR is revealed through synthetic lethality.
    7. N-terminus verified by Edman degradation on mature peptide
      Title: Major proteins of the Escherichia coli outer cell envelope membrane. Preliminary characterization of the phage lambda receptor protein.
    8. all aromatic residues provide some steric hindrance for ion transport through LamB
      Title: Site-directed mutagenesis of the greasy slide aromatic residues within the LamB (maltoporin) channel of Escherichia coli: effect on ion and maltopentaose transport.
    9. demonstrated that LamB moves along the bacterial surface and that these movements are restricted by an underlying dynamic spiral pattern
      Title: Complex spatial distribution and dynamics of an abundant Escherichia coli outer membrane protein, LamB.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carbohydrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables maltodextrin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables maltodextrin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables maltose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables maltose transporting porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables porin activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables porin activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables virus receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in carbohydrate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maltodextrin transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maltodextrin transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maltose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maltose transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polysaccharide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer membrane protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of pore complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maltose outer membrane channel/phage lambda receptor protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4247971..4249311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418460.1 maltose outer membrane channel/phage lambda receptor protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418460.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X5NX10
      Conserved Domains (1) summary
      PRK09360
      Location:1 → 446
      lamB; maltoporin LamB
    Nucleotide Protein
    Heading Accession and Version

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