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    soxR DNA-binding transcriptional dual regulator SoxR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948566, updated on 3-Dec-2024

    Summary

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    Official Symbol
    soxR
    Official Full Name
    DNA-binding transcriptional dual regulator SoxR
    Primary source
    ECOCYC:EG10957
    Locus tag
    b4063
    See related
    ASAP:ABE-0013316
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4055; marC
    Summary
    SoxR responds to superoxide and activates the SoxS global regulator in a regulatory cascade; reduced by RseC and RsxABCDGE. [More information is available at EcoGene: EG10957]. SoxR belongs to the MerR family of transcriptional regulators. [More information is available at EcoCyc: EG10957].
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    Genomic context

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    Sequence:
    NC_000913.3 (4277469..4277933)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene c-di-GMP phosphodiesterase PdeC Neighboring gene DNA-binding transcriptional dual regulator SoxS Neighboring gene ncRNA Neighboring gene guanine/hypoxanthine transporter GhxP Neighboring gene putative transporter YjcE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response. Demple B, et al. Biochem Soc Symp, 1999. PMID 10207625
    2. Binuclear [2Fe-2S] clusters in the Escherichia coli SoxR protein and role of the metal centers in transcription. Hidalgo E, et al. J Biol Chem, 1995 Sep 8. PMID 7673113
    3. An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein. Hidalgo E, et al. EMBO J, 1994 Jan 1. PMID 8306957, Free PMC Article
    4. Activation of SoxR-dependent transcription in vitro by noncatalytic or NifS-mediated assembly of [2Fe-2S] clusters into apo-SoxR. Hidalgo E, et al. J Biol Chem, 1996 Mar 29. PMID 8631739
    5. Glutathione-mediated destabilization in vitro of [2Fe-2S] centers in the SoxR regulatory protein. Ding H, et al. Proc Natl Acad Sci U S A, 1996 Sep 3. PMID 8790350, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The findings clearly support the idea that lysine is critical to the response to superoxide and further transcriptional activity of SoxR.
      Title: Rational Tuning of Superoxide Sensitivity in SoxR, the [2Fe-2S] Transcription Factor: Implications of Species-Specific Lysine Residues.
    2. Polyamines are involved in easing of oxidative stress through stimulation of synthesis of SoxR, EmrR and GshA together with RpoS.
      Title: Three members of polyamine modulon under oxidative stress conditions: two transcription factors (SoxR and EmrR) and a glutathione synthetic enzyme (GshA).
    3. Data indicate reaction of nitric oxide with transcription factor SoxR by pulse radiolysis.
      Title: Mechanistic studies on formation of the dinitrosyl iron complex of the [2Fe-2S] cluster of SoxR protein.
    4. This review focuses on the mechanisms by which SoxR proteins respond to oxidative stress.
      Title: Oxidative stress sensing by the iron-sulfur cluster in the transcription factor, SoxR.
    5. study compared responsiveness of SoxRs from Streptomyces coelicolor, Pseudomonas aeruginosa and E. coli towards redox-active compounds; ScSoxR is the most limited in the range of chemicals to which it responds and has highest reduction potential; both kinetic and redox potential factors determine range of effective chemicals
      Title: Comparative study of SoxR activation by redox-active compounds.
    6. Analysis of apo-SoxR binding determines that the effect of apo-SoxR on DNA triple-crossover molecules (TX) in the cohesive tract of a DNA-based mechanical device is similar to the effect of shortening the device by 2 base pairs.
      Title: A DNA-based nanomechanical device used to characterize the distortion of DNA by Apo-SoxR protein.
    7. The results indicate that activation of the soxRS regulon in E. coli cells exposed to superoxide-propagating compounds can be triggered by depletion of the NADPH stock rather than accumulation of superoxide itself.
      Title: The soxRS response of Escherichia coli can be induced in the absence of oxidative stress and oxygen by modulation of NADPH content.
    8. Conformational changes induced upon reduction of DNA-bound SoxR are not significantly different from those of DNA-free SoxR.
      Title: Protein conformational changes of the oxidative stress sensor, SoxR, upon redox changes of the [2Fe-2S] cluster probed with ultraviolet resonance Raman spectroscopy.
    9. mutant SoxR proteins contributed to the multiple-antibiotic resistance phenotypes of the clinical strains and were sufficient to confer multiple-antibiotic resistance in a fresh genetic background
      Title: Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator SoxR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4277469..4277933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418487.1 DNA-binding transcriptional dual regulator SoxR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418487.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0G411
      Conserved Domains (1) summary
      PRK15002
      Location:1 → 154
      PRK15002; redox-sensitive transcriptional activator SoxR
    Nucleotide Protein
    Heading Accession and Version

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