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    tamB translocation and assembly module subunit TamB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948742, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tamB
    Official Full Name
    translocation and assembly module subunit TamB
    Primary source
    ECOCYC:G7875
    Locus tag
    b4221
    See related
    ASAP:ABE-0013811
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4217; ytfN; ytfO
    Summary
    May have signal peptide (weak prediction), or an uncleaved signal anchor (predicted single N-terminal TM region). [More information is available at EcoGene: EG12514].
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    Genomic context

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    Sequence:
    NC_000913.3 (4444112..4447891)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative cadaverine/putrescine exporter Neighboring gene methionine sulfoxide reductase A Neighboring gene translocation and assembly module subunit TamA Neighboring gene gamma-glutamylamine cyclotransferase family protein YtfP Neighboring gene ChpS antitoxin of the ChpB-ChpS toxin-antitoxin system Neighboring gene endoribonuclease toxin ChpB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine. Stubenrauch C, et al. Nat Microbiol, 2016 May 16. PMID 27572967
    2. The conserved carboxyl domain of MorC, an inner membrane protein of Aggregatibacter actinomycetemcomitans, is essential for membrane function. Smith KP, et al. Mol Oral Microbiol, 2016 Feb. PMID 26205976, Free PMC Article
    3. Proteus mirabilis genes that contribute to pathogenesis of urinary tract infection: identification of 25 signature-tagged mutants attenuated at least 100-fold. Burall LS, et al. Infect Immun, 2004 May. PMID 15102805, Free PMC Article
    4. Application of a novel multi-screening signature-tagged mutagenesis assay for identification of Klebsiella pneumoniae genes essential in colonization and infection. Struve C, et al. Microbiology (Reading), 2003 Jan. PMID 12576590
    5. Global landscape of cell envelope protein complexes in Escherichia coli. Babu M, et al. Nat Biotechnol, 2018 Jan. PMID 29176613, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YhdP, TamB, and YdbH Are Redundant but Essential for Growth and Lipid Homeostasis of the Gram-Negative Outer Membrane.
      Title: YhdP, TamB, and YdbH Are Redundant but Essential for Growth and Lipid Homeostasis of the Gram-Negative Outer Membrane.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein localization to outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TAM protein secretion complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TAM protein secretion complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TAM protein secretion complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translocation and assembly module subunit TamB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4444112..4447891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418642.1 translocation and assembly module subunit TamB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418642.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3R0N0M6, A0A8S7E8E4
      Conserved Domains (1) summary
      COG2911
      Location:1 → 1259
      TamB; Autotransporter translocation and assembly factor TamB [Intracellular trafficking, secretion, and vesicular transport]
    Nucleotide Protein
    Heading Accession and Version

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