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    kefC K(+) : H(+) antiporter KefC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944773, updated on 17-Dec-2024

    Summary

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    Official Symbol
    kefC
    Official Full Name
    K(+) : H(+) antiporter KefC
    Primary source
    ECOCYC:EG10521
    Locus tag
    b0047
    See related
    ASAP:ABE-0000161
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0048; trkC
    Summary
    KefB and KefC are two independent glutathione-regulated potassium efflux systems, which play a role in protecting the cell from electrophile toxicity. [More information is available at EcoCyc: EG10521].
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    Genomic context

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    Sequence:
    NC_000913.3 (47769..49631)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase FixC Neighboring gene putative ferredoxin FixX Neighboring gene putative transporter YaaU Neighboring gene regulator of KefC-mediated potassium transport and quinone oxidoreductase Neighboring gene dihydrofolate reductase Neighboring gene diadenosine tetraphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and mechanism of the K(+)/H(+) exchanger KefC. Gulati A, et al. Nat Commun, 2024 Jun 4. PMID 38834573, Free PMC Article
    2. The putative Na+/H+ antiporter (NapA) of Enterococcus hirae is homologous to the putative K+/H+ antiporter (KefC) of Escherichia coli. Reizer J, et al. FEMS Microbiol Lett, 1992 Jul 1. PMID 1325937
    3. The distribution of homologues of the Escherichia coli KefC K(+)-efflux system in other bacterial species. Douglas RM, et al. J Gen Microbiol, 1991 Aug. PMID 1955875
    4. The K(+)-efflux system, KefC, in Escherichia coli: genetic evidence for oligomeric structure. Douglas RM, et al. Mol Membr Biol, 1994 Jan-Mar. PMID 8019602
    5. Nucleotide sequence of the E coli gene coding for dihydrofolate reductase. Smith DR, et al. Nucleic Acids Res, 1980 May 24. PMID 6159575, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure and mechanism of the K[+]/H[+] exchanger KefC.
      Title: Structure and mechanism of the K(+)/H(+) exchanger KefC.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutathione-regulated potassium exporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione-regulated potassium exporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables toxic substance binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables toxic substance binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular pH elevation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to methylglyoxal IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to methylglyoxal IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of potassium:proton antiporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    K(+) : H(+) antiporter KefC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      47769..49631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414589.1 K(+) : H(+) antiporter KefC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414589.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FQ59, A0A6M9X2P6
      Conserved Domains (1) summary
      PRK03562
      Location:1 → 620
      PRK03562; glutathione-regulated potassium-efflux system protein KefC; Provisional
    Nucleotide Protein
    Heading Accession and Version

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