U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    apaH diadenosine tetraphosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944770, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    apaH
    Official Full Name
    diadenosine tetraphosphatase
    Primary source
    ECOCYC:EG10048
    Locus tag
    b0049
    See related
    ASAP:ABE-0000167
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cfcB; ECK0050
    Summary
    Required for invasion of cultured mammalian cells by S. typhimurium. [More information is available at EcoGene: EG10048]. The apaH gene encodes diadenosine tetraphosphatase (diadenosine 5', 5'''-P1, P4-tetraphosphate pyrophosphohydrolase) . [More information is available at EcoCyc: EG10048].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (50380..51222, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulator of KefC-mediated potassium transport and quinone oxidoreductase Neighboring gene K(+) : H(+) antiporter KefC Neighboring gene dihydrofolate reductase Neighboring gene DUF525 domain-containing protein ApaG Neighboring gene 16S rRNA m(6)2A1518,m(6)2A1519 dimethyltransferase Neighboring gene 4-hydroxythreonine-4-phosphate dehydrogenase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Conservation analysis and structure prediction of the protein serine/threonine phosphatases. Sequence similarity with diadenosine tetraphosphatase from Escherichia coli suggests homology to the protein phosphatases. Barton GJ, et al. Eur J Biochem, 1994 Feb 15. PMID 8119291
    2. Cloning and nucleotide sequence of a negative regulator gene for Klebsiella aerogenes arylsulfatase synthesis and identification of the gene as folA. Azakami H, et al. J Bacteriol, 1992 Apr. PMID 1551851, Free PMC Article
    3. Fluoride is a strong and specific inhibitor of (asymmetrical) Ap4A hydrolases. Guranowski A. FEBS Lett, 1990 Mar 26. PMID 2159411
    4. An apaH mutation causes AppppA to accumulate and affects motility and catabolite repression in Escherichia coli. Farr SB, et al. Proc Natl Acad Sci U S A, 1989 Jul. PMID 2544886, Free PMC Article
    5. Studies on some specific Ap4A-degrading enzymes with the use of various methylene analogues of P1P4-bis-(5',5'''-adenosyl) tetraphosphate. Guranowski A, et al. Biochem J, 1989 Aug 15. PMID 2554885, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: The gene for Escherichia coli diadenosine tetraphosphatase is located immediately clockwise to folA and forms an operon with ksgA.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bis(5'-nucleosyl)-tetraphosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA decapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA decapping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA decapping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleobase-containing small molecule interconversion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    diadenosine tetraphosphatase
    NP_414591.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      50380..51222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414591.1 diadenosine tetraphosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414591.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9QAX2
      Conserved Domains (1) summary
      TIGR00668
      Location:1 → 279
      apaH; bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.