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    glxR tartronate semialdehyde reductase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945146, updated on 17-Dec-2024

    Summary

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    Official Symbol
    glxR
    Official Full Name
    tartronate semialdehyde reductase 2
    Primary source
    ECOCYC:G6278
    Locus tag
    b0509
    See related
    ASAP:ABE-0001759
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0502; glxB1; ybbQ
    Summary
    Tartronate semialdehyde reductase 2 (GlxR) catalyzes the reversible reactions of NAD+-dependent oxidation of D-glycerate and the NADH-dependent reduction of tartronate semialdehyde . [More information is available at EcoCyc: G6278].
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    Genomic context

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    Sequence:
    NC_000913.3 (536586..537464)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glyoxylate carboligase Neighboring gene hydroxypyruvate isomerase Neighboring gene putative allantoin transporter Neighboring gene allantoinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New developments in our understanding of the beta-hydroxyacid dehydrogenases. Njau RK, et al. Chem Biol Interact, 2001 Jan 30. PMID 11306094
    2. Novel beta -hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae. Njau RK, et al. J Biol Chem, 2000 Dec 8. PMID 10978349
    3. RutR is the uracil/thymine-sensing master regulator of a set of genes for synthesis and degradation of pyrimidines. Shimada T, et al. Mol Microbiol, 2007 Nov. PMID 17919280
    4. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071
    5. Biochemical evidence that Escherichia coli hyi (orf b0508, gip) gene encodes hydroxypyruvate isomerase. Ashiuchi M, et al. Biochim Biophys Acta, 1999 Nov 16. PMID 10561547

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-hydroxy-3-oxopropionate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-hydroxy-3-oxopropionate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within allantoin assimilation pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glycolate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glyoxylate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glyoxylate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tartronate semialdehyde reductase 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      536586..537464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415042.1 tartronate semialdehyde reductase 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415042.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ALN3
      Conserved Domains (1) summary
      PRK15059
      Location:1 → 292
      PRK15059; 2-hydroxy-3-oxopropionate reductase
    Nucleotide Protein
    Heading Accession and Version

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