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    sxy transcriptional coactivator for CRP [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946504, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sxy
    Official Full Name
    transcriptional coactivator for CRP
    Primary source
    ECOCYC:G6494
    Locus tag
    b0959
    See related
    ASAP:ABE-0003249
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0950; yccR
    Summary
    CRP-S are specialized CRP-dependent promoters that also require the Sxy gene product for expression (Cameron, 2006). [More information is available at EcoGene: EG13720]. Sxy is required for transcription from a subset of CRP-activated promoters. [More information is available at EcoCyc: G6494].
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    Genomic context

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    Sequence:
    NC_000913.3 (1021138..1021767)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene outer membrane protein A Neighboring gene cell division inhibitor SulA Neighboring gene putative transporter YccS Neighboring gene PF03733 family inner membrane protein YccF Neighboring gene DNA helicase IV

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. sxy-1, a Haemophilus influenzae mutation causing greatly enhanced spontaneous competence. Redfield RJ. J Bacteriol, 1991 Sep. PMID 1653215, Free PMC Article
    2. CRP-dependent positive autoregulation and proteolytic degradation regulate competence activator Sxy of Escherichia coli. Jaskólska M, et al. Mol Microbiol, 2015 Mar. PMID 25491382
    3. Natural DNA uptake by Escherichia coli. Sinha S, et al. PLoS One, 2012. PMID 22532864, Free PMC Article
    4. Sxy induces a CRP-S regulon in Escherichia coli. Sinha S, et al. J Bacteriol, 2009 Aug. PMID 19502395, Free PMC Article
    5. Non-canonical CRP sites control competence regulons in Escherichia coli and many other gamma-proteobacteria. Cameron AD, et al. Nucleic Acids Res, 2006. PMID 17068078, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA import into cell involved in transformation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA import into cell involved in transformation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of competence for transformation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of type IV pilus biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional coactivator for CRP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1021138..1021767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415479.1 transcriptional coactivator for CRP [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415479.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L9IEX6
      Conserved Domains (2) summary
      COG3070
      Location:2 → 121
      TfoX; Transcriptional regulator of competence genes, TfoX/Sxy family [Transcription]
      pfam04994
      Location:115 → 195
      TfoX_C; TfoX C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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