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    lpxL lauroyl acyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946216, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lpxL
    Official Full Name
    lauroyl acyltransferase
    Primary source
    ECOCYC:EG10464
    Locus tag
    b1054
    See related
    ASAP:ABE-0003574
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1039; htrB; waaM
    Summary
    Lauroyl acyltransferase incorporates a laurate residue into KDO2-lipid IVA from lauroyl-ACP . [More information is available at EcoCyc: EG10464].
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    Genomic context

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    Sequence:
    NC_000913.3 (1115662..1116582, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene acidic protein MsyB Neighboring gene efflux pump MdtG Neighboring gene tRNA U34 hydroxylase TrhO Neighboring gene protein YceI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the Escherichia coli htrB gene, whose product is essential for bacterial viability above 33 degrees C in rich media. Karow M, et al. J Bacteriol, 1991 Jan. PMID 1846149, Free PMC Article
    2. tRNA2Thr complements temperature sensitivity caused by null mutations in the htrB gene in Escherichia coli. Mohri Y, et al. J Bacteriol, 2003 Mar. PMID 12591892, Free PMC Article
    3. Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars. Reynolds CM, et al. Biochemistry, 2009 Oct 13. PMID 19754149, Free PMC Article
    4. Sequencing, mutational analysis, and transcriptional regulation of the Escherichia coli htrB gene. Karow M, et al. Mol Microbiol, 1991 Sep. PMID 1840644
    5. A triple mutant of Escherichia coli lacking secondary acyl chains on lipid A. Vorachek-Warren MK, et al. J Biol Chem, 2002 Apr 19. PMID 11830595

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables Kdo2-lipid IVA acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Kdo2-lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid A biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lauroyl acyltransferase
    NP_415572.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1115662..1116582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415572.1 lauroyl acyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415572.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FKS8, A0A376MV30
      Conserved Domains (1) summary
      PRK06860
      Location:1 → 306
      PRK06860; lipid A biosynthesis lauroyl acyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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