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    cobB CobB-S;protein-lysine deacetylase/desuccinylase/lipoamidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945687, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cobB
    Official Full Name
    CobB-S;protein-lysine deacetylase/desuccinylase/lipoamidase
    Primary source
    ECOCYC:G6577
    Locus tag
    b1120
    See related
    ASAP:ABE-0003781
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1106; ycfY
    Summary
    Acetyl CoA synthase Acs is activated by sirtuin homolog CobB-mediated deacetylation of K609 in Salmonella (Starai, 2002). [More information is available at EcoGene: EG13443]. The CobB protein belongs to the sirtuins, a broadly conserved family of NAD+-dependent protein deacetylases. [More information is available at EcoCyc: G6577].
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    Genomic context

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    Sequence:
    NC_000913.3 (1179520..1180359)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipoprotein release complex - ATP binding subunit Neighboring gene lipoprotein release complex - inner membrane subunit Neighboring gene N-acetyl-D-glucosamine kinase Neighboring gene putative inner membrane protein YcfZ Neighboring gene putative inner membrane protein YmfA Neighboring gene spermidine preferential ABC transporter periplasmic binding protein Neighboring gene spermidine preferential ABC transporter membrane subunit PotC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes. Rowland EA, et al. mBio, 2017 Sep 12. PMID 28900027, Free PMC Article
    2. The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites. AbouElfetouh A, et al. Microbiologyopen, 2015 Feb. PMID 25417765, Free PMC Article
    3. Identification of lysine succinylation substrates and the succinylation regulatory enzyme CobB in Escherichia coli. Colak G, et al. Mol Cell Proteomics, 2013 Dec. PMID 24176774, Free PMC Article
    4. CobB regulates Escherichia coli chemotaxis by deacetylating the response regulator CheY. Li R, et al. Mol Microbiol, 2010 Jun 1. PMID 20345663, Free PMC Article
    5. YiaC and CobB regulate lysine lactylation in Escherichia coli. Dong H, et al. Nat Commun, 2022 Nov 4. PMID 36333310, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YiaC and CobB regulate lysine lactylation in Escherichia coli.
      Title: YiaC and CobB regulate lysine lactylation in Escherichia coli.
    2. discovered that CobB acts as a lipoamidase; results indicate that CobB has the ability to regulate pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase activity under different growth conditions
      Title: Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes.
    3. CobB can reverse acetylation regardless of acetyl donor or acetylation mechanism.
      Title: The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites.
    4. CobB is a bifunctional enzyme with lysine desuccinylation and deacetylation activities.
      Title: Identification of lysine succinylation substrates and the succinylation regulatory enzyme CobB in Escherichia coli.
    5. CobB play crucial roles in the transcription regulation of the periplasmic stress-responsive promoter cpxP when cells of Escherichia coli grow in the presence of glucose, an environment that induces protein acetylation
      Title: Involvement of protein acetylation in glucose-induced transcription of a stress-responsive promoter.
    6. Results suggest that CobB regulates E. coli chemotaxis by deacetylating CheY.
      Title: CobB regulates Escherichia coli chemotaxis by deacetylating the response regulator CheY.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD-dependent protein de-2-hydroxyisobutyrylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD-dependent protein lysine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K14 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K18 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K56 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity, NAD-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-malonyllysine demalonylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-succinyllysine desuccinylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CobB-S;protein-lysine deacetylase/desuccinylase/lipoamidase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1179520..1180359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415638.3 protein-lysine deacetylase/desuccinylase/lipoamidase [Escherichia coli str. K-12 substr. MG1655]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T3URZ6
      Conserved Domains (1) summary
      PRK00481
      Location:31 → 271
      PRK00481; NAD-dependent deacetylase; Provisional

    2. YP_010051180.1 CobB-S [Escherichia coli str. K-12 substr. MG1655]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3M5H1
      Conserved Domains (1) summary
      PRK00481
      Location:1 → 234
      PRK00481; NAD-dependent deacetylase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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