U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dhaK dihydroxyacetone kinase subunit K [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945747, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dhaK
    Official Full Name
    dihydroxyacetone kinase subunit K
    Primary source
    ECOCYC:G6627
    Locus tag
    b1200
    See related
    ASAP:ABE-0004029
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dhaK1; ECK1188; ycgT
    Summary
    DhaK is similar to N-terminal half of single protein DHA kinases. [More information is available at EcoGene: EG13901]. The K subunit is similar to the N-terminal half of ATP-dependent dihydroxyacetone kinase of Citrobacter freundii and eukaryotes. [More information is available at EcoCyc: G6627].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1249768..1250838, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene dihydroxyacetone kinase subunit M Neighboring gene dihydroxyacetone kinase subunit L Neighboring gene DNA-binding transcriptional dual regulator DhaR Neighboring gene putative autotransporter adhesin YcgV

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase. Shi R, et al. Proc Natl Acad Sci U S A, 2011 Jan 25. PMID 21209328, Free PMC Article
    2. Heterodimeric dihydroxyacetone kinase from a ptsI mutant of Escherichia coli. Beutler R, et al. Microbiology (Reading), 2001 Feb. PMID 11158340
    3. Coiled-coil helix rotation selects repressing or activating state of transcriptional regulator DhaR. Shi R, et al. Structure, 2014 Mar 4. PMID 24440518
    4. A mechanism of covalent substrate binding in the x-ray structure of subunit K of the Escherichia coli dihydroxyacetone kinase. Siebold C, et al. Proc Natl Acad Sci U S A, 2003 Jul 8. PMID 12813127, Free PMC Article
    5. Phosphoenolpyruvate- and ATP-dependent dihydroxyacetone kinases: covalent substrate-binding and kinetic mechanism. Garcia-Alles LF, et al. Biochemistry, 2004 Oct 19. PMID 15476397

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the structure of dihydroxyacetone kinase complex DhaK undergoes significant conformational changes to accommodate binding of DhaL.
      Title: Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycerone kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerone kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoenolpyruvate-glycerone phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoenolpyruvate-glycerone phosphotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphoenolpyruvate-glycerone phosphotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in carbohydrate phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycerol to glycerone phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ketone catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monosaccharide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyruvate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    dihydroxyacetone kinase subunit K
    NP_415718.6

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1249768..1250838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415718.6 dihydroxyacetone kinase subunit K [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415718.6

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DTD8
      Conserved Domains (1) summary
      PRK11468
      Location:1 → 356
      PRK11468; dihydroxyacetone kinase subunit DhaK; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.