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    hdhA 7-alpha-hydroxysteroid dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946151, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hdhA
    Official Full Name
    7-alpha-hydroxysteroid dehydrogenase
    Primary source
    ECOCYC:EG10425
    Locus tag
    b1619
    See related
    ASAP:ABE-0005419
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1614; hsd; hsdH
    Summary
    7--hydroxysteroid dehydrogenase catalyzes the dehydroxylation of cholic and chenodeoxycholic acids, major human bile acids, yielding 7-oxocholic and 7-oxochenodeoxycholic acids, respectively. [More information is available at EcoCyc: EG10425].
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    Genomic context

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    Sequence:
    NC_000913.3 (1697273..1698040, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glucuronide:H(+) symporter Neighboring gene beta-glucuronidase Neighboring gene DNA-binding transcriptional repressor UidR Neighboring gene DNA-binding transcriptional repressor MalI Neighboring gene PTS enzyme IIBC component MalX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of the Ser146, Tyr159, and Lys163 residues in the catalytic action of 7alpha-hydroxysteroid dehydrogenase from Escherichia coli. Tanabe T, et al. J Biochem, 1998 Sep. PMID 9722677
    2. Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli. Tanaka N, et al. Biochemistry, 1996 Jun 18. PMID 8672472
    3. Location of the 7 alpha-hydroxysteroid dehydrogenase gene (hdhA) on the physical map of the Escherichia coli chromosome. Yoshimoto T, et al. J Bacteriol, 1993 Sep. PMID 8366061, Free PMC Article
    4. Cloning and sequencing of the 7 alpha-hydroxysteroid dehydrogenase gene from Escherichia coli HB101 and characterization of the expressed enzyme. Yoshimoto T, et al. J Bacteriol, 1991 Apr. PMID 2007545, Free PMC Article
    5. Sequencing and high expression of aminopeptidase P gene from Escherichia coli HB101. Yoshimoto T, et al. J Biochem, 1989 Mar. PMID 2659585

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cholate 7-alpha-dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholate 7-alpha-dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cholate 7-alpha-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in bile acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    7-alpha-hydroxysteroid dehydrogenase
    NP_416136.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1697273..1698040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416136.1 7-alpha-hydroxysteroid dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416136.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WUV7
      Conserved Domains (1) summary
      PRK06113
      Location:1 → 255
      PRK06113; 7-alpha-hydroxysteroid dehydrogenase; Validated
    Nucleotide Protein
    Heading Accession and Version

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