U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sppA protease IV, a signal peptide peptidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946281, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sppA
    Official Full Name
    protease IV, a signal peptide peptidase
    Primary source
    ECOCYC:EG10968
    Locus tag
    b1766
    See related
    ASAP:ABE-0005880
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1764
    Summary
    Protease IV is an endopeptidase that degrades cleaved signal peptide . [More information is available at EcoCyc: EG10968].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1848837..1850693)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene selenide, water dikinase Neighboring gene putative oxidoreductase YdjA Neighboring gene L-asparaginase 1 Neighboring gene nicotinamidase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Minimum substrate sequence for signal peptidase I of Escherichia coli. Dev IK, et al. J Biol Chem, 1990 Nov 25. PMID 2243078
    2. Mutational evidence of transition state stabilization by serine 88 in Escherichia coli type I signal peptidase. Carlos JL, et al. Biochemistry, 2000 Jun 20. PMID 10852727
    3. Escherichia coli signal peptide peptidase A is a serine-lysine protease with a lysine recruited to the nonconserved amino-terminal domain in the S49 protease family. Wang P, et al. Biochemistry, 2008 Jun 17. PMID 18476724, Free PMC Article
    4. Degradation of a signal peptide by protease IV and oligopeptidase A. Novak P, et al. J Bacteriol, 1988 Nov. PMID 3053642, Free PMC Article
    5. Localization and purification of two enzymes from Escherichia coli capable of hydrolyzing a signal peptide. Novak P, et al. J Biol Chem, 1986 Jan 5. PMID 3510201

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal peptide processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protease IV, a signal peptide peptidase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1848837..1850693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416280.1 protease IV, a signal peptide peptidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416280.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8N9T4
      Conserved Domains (1) summary
      PRK10949
      Location:1 → 618
      PRK10949; signal peptide peptidase SppA
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.