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    cheR chemotaxis protein methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946396, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cheR
    Official Full Name
    chemotaxis protein methyltransferase
    Primary source
    ECOCYC:EG10148
    Locus tag
    b1884
    See related
    ASAP:ABE-0006286
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cheX; ECK1885
    Summary
    Overexpression causes filamentous biofilm formation. otherPDB (S .typhimurium): [More information is available at EcoGene: EG10148]. CheR is a component of the adaptation pathway of the chemotaxis sensory transduction system of Escherichia coli. [More information is available at EcoCyc: EG10148].
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    Genomic context

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    Sequence:
    NC_000913.3 (1968504..1969364, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene chemotaxis protein CheY Neighboring gene protein-glutamate methylesterase/protein glutamine deamidase Neighboring gene methyl-accepting chemotaxis protein Tap Neighboring gene methyl-accepting chemotaxis protein Tar

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Failure of sensory adaptation in bacterial mutants that are defective in a protein methylation reaction. Goy MF, et al. Cell, 1978 Dec. PMID 365357
    2. E. coli superdiffusion and chemotaxis-search strategy, precision, and motility. Matthäus F, et al. Biophys J, 2009 Aug 19. PMID 19686641, Free PMC Article
    3. Molecular modeling of flexible arm-mediated interactions between bacterial chemoreceptors and their modification enzyme. Muppirala UK, et al. Protein Sci, 2009 Aug. PMID 19606502, Free PMC Article
    4. Dual recognition of the bacterial chemoreceptor by chemotaxis-specific domains of the CheR methyltransferase. Shiomi D, et al. J Biol Chem, 2002 Nov 1. PMID 12101179
    5. The receptor docking segment and S-adenosyl-L-homocysteine bind independently to the methyltransferase of bacterial chemotaxis. Yi X, et al. Biochim Biophys Acta, 2002 Apr 1. PMID 11983418

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The exchange of CheB and CheR at receptor clusters shows a strong dependency on the receptor modification.
      Title: Effects of receptor modification and temperature on dynamics of sensory complexes in Escherichia coli chemotaxis.
    2. These studies revealed that the chemotactic response in swimming bacteria is fined-tuned to wild-type level of the [CheR]/[CheB] ratio.
      Title: Fine-tuning of chemotactic response in E. coli determined by high-throughput capillary assay.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-glutamate O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glutamate O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of methyl accepting chemotaxis protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of methyl accepting chemotaxis protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chemotaxis protein methyltransferase
    NP_416398.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1968504..1969364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416398.1 chemotaxis protein methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416398.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M6T2
      Conserved Domains (1) summary
      PRK10611
      Location:1 → 286
      PRK10611; protein-glutamate O-methyltransferase CheR
    Nucleotide Protein
    Heading Accession and Version

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