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    udk uridine/cytidine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946597, updated on 3-Dec-2024

    Summary

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    Official Symbol
    udk
    Official Full Name
    uridine/cytidine kinase
    Primary source
    ECOCYC:EG11701
    Locus tag
    b2066
    See related
    ASAP:ABE-0006840
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2060
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    Genomic context

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    Sequence:
    NC_000913.3 (2142307..2142948, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative assembly protein AsmA Neighboring gene dCTP deaminase Neighboring gene putative diguanylate cyclase DgcE Neighboring gene DNA-3-methyladenine glycosylase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Escherichia coli udk mimics the absence of T7 Gp2 function and thereby abrogates successful infection by T7 phage. Shadrin A, et al. Microbiology (Reading), 2013 Feb. PMID 23242801, Free PMC Article
    2. Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk. Qimron U, et al. Mol Microbiol, 2008 Jan. PMID 18067538
    3. Location of the udk gene on the physical map of Escherichia coli. Neuhard J, et al. J Bacteriol, 1993 Sep. PMID 8366067, Free PMC Article
    4. Uridine-cytidine kinase from Escherichia coli. Valentin-Hansen P. Methods Enzymol, 1978. PMID 211379
    5. Mapping of the gene for cytidine deaminase (cdd) in Escherichia coli K-12. Josephsen J, et al. J Bacteriol, 1983 Apr. PMID 6339482, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It seems that overexpression of udk reduces Gp2 stability and functionality during T7 infection, which consequently results in inadequate inhibition of host RNAp and in the accumulation of early T7 transcripts.
      Title: Overexpression of Escherichia coli udk mimics the absence of T7 Gp2 function and thereby abrogates successful infection by T7 phage.
    2. Inhibition of T7 phage growth by udk overexpression can be overcome by inhibition of host RNA polymerase.
      Title: Inadequate inhibition of host RNA polymerase restricts T7 bacteriophage growth on hosts overexpressing udk.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytidine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uridine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CTP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uridine/cytidine kinase
    NP_416570.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2142307..2142948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416570.2 uridine/cytidine kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416570.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      C3SCV1
      Conserved Domains (1) summary
      PRK05480
      Location:3 → 213
      PRK05480; uridine/cytidine kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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