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    napC periplasmic nitrate reductase cytochrome c protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946706, updated on 3-Dec-2024

    Summary

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    Official Symbol
    napC
    Official Full Name
    periplasmic nitrate reductase cytochrome c protein
    Primary source
    ECOCYC:EG12060
    Locus tag
    b2202
    See related
    ASAP:ABE-0007281
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2194; yejX
    Summary
    NapC is essential for electron transfer from both ubiquinol and menaquinol to NapAB. [More information is available at EcoGene: EG12060]. The napC gene encodes a membrane-bound tetraheme cytochrome c protein, which passes electrons either from NapGH or directly from the quinone pool to NapB . [More information is available at EcoCyc: EG12060].
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    Genomic context

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    Sequence:
    NC_000913.3 (2297657..2298259, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome c maturation protein D Neighboring gene cytochrome c maturation protein C Neighboring gene cytochrome c maturation protein B Neighboring gene cytochrome c maturation protein A Neighboring gene periplasmic nitrate reductase cytochrome c550 protein Neighboring gene ferredoxin-type protein NapH Neighboring gene ferredoxin-type protein NapG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recombinant nematode anticoagulant protein c2 inhibits cell invasion by decreasing uPA expression in NSCLC cells. Tong Y, et al. Oncol Rep, 2015 Apr. PMID 25672417
    2. Dissimilatory iron reduction in Escherichia coli: identification of CymA of Shewanella oneidensis and NapC of E. coli as ferric reductases. Gescher JS, et al. Mol Microbiol, 2008 May. PMID 18394146
    3. Competition between Escherichia coli strains expressing either a periplasmic or a membrane-bound nitrate reductase: does Nap confer a selective advantage during nitrate-limited growth? Potter LC, et al. Biochem J, 1999 Nov 15. PMID 10548536, Free PMC Article
    4. The molybdate-responsive Escherichia coli ModE transcriptional regulator coordinates periplasmic nitrate reductase (napFDAGHBC) operon expression with nitrate and molybdate availability. McNicholas PM, et al. J Bacteriol, 2002 Jun. PMID 12029041, Free PMC Article
    5. STUDIES ON THE PYRIDINE NUCLEOTIDE SPECIFICITY OF NITRATE REDUCTASE IN HIGHER PLANTS AND ITS RELATIONSHIP TO SULFHYDRYL LEVEL. BEEVERS L, et al. Biochim Biophys Acta, 1964 Sep 18. PMID 14209328

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that rNAPc2 may be a potent agent for the prevention of NSCLC progression.
      Title: Recombinant nematode anticoagulant protein c2 inhibits cell invasion by decreasing uPA expression in NSCLC cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaerobic respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within anaerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in denitrification pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    periplasmic nitrate reductase cytochrome c protein
    NP_416706.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2297657..2298259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416706.1 periplasmic nitrate reductase cytochrome c protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416706.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377D097
      Conserved Domains (1) summary
      PRK10617
      Location:1 → 200
      PRK10617; cytochrome c-type protein NapC; Provisional
    Nucleotide Protein
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