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    arnT lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947297, updated on 3-Dec-2024

    Summary

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    Official Symbol
    arnT
    Official Full Name
    lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
    Primary source
    ECOCYC:G7170
    Locus tag
    b2257
    See related
    ASAP:ABE-0007464
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2250; pmrK; yfbI
    Summary
    Inner membane protein. basRS regulon. [More information is available at EcoGene: EG14093]. ArnT is the 4-amino-4-deoxy-L-arabinose (L-Ara4N) transferase that catalyzes addition of L-Ara4N to lipid A under some conditions (polymyxin resistant mutants) . [More information is available at EcoCyc: G7170].
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    Genomic context

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    Sequence:
    NC_000913.3 (2370908..2372560)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase Neighboring gene fused UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronate dehydrogenase Neighboring gene putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit Neighboring gene signal transduction protein PmrD Neighboring gene o-succinylbenzoate--CoA ligase Neighboring gene o-succinylbenzoate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of the L-Ara4N transferase protein ArnT from Salmonella typhimurium. Bretscher LE, et al. Protein Expr Purif, 2006 Mar. PMID 16226890
    2. Resistance to the antimicrobial peptide polymyxin requires myristoylation of Escherichia coli and Salmonella typhimurium lipid A. Tran AX, et al. J Biol Chem, 2005 Aug 5. PMID 15951433
    3. An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor. Trent MS, et al. J Biol Chem, 2001 Nov 16. PMID 11535604
    4. The pleiotropic two-component regulatory system PhoP-PhoQ. Groisman EA. J Bacteriol, 2001 Mar. PMID 11222580, Free PMC Article
    5. Fe(III)-mediated cellular toxicity. Chamnongpol S, et al. Mol Microbiol, 2002 Aug. PMID 12139617

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Purified recombinant ArnT protein was shown to be highly alpha-helical as determined by circular dichroism analysis.
      Title: Purification and characterization of the L-Ara4N transferase protein ArnT from Salmonella typhimurium.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-amino-4-deoxy-L-arabinose transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to iron(III) ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to iron(III) ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to iron(III) ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
    NP_416760.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2370908..2372560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416760.1 lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416760.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7R9Z6
      Conserved Domains (1) summary
      PRK13279
      Location:1 → 549
      arnT; lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase
    Nucleotide Protein
    Heading Accession and Version

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