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    nuoE NADH:quinone oxidoreductase subunit E [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946746, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nuoE
    Official Full Name
    NADH:quinone oxidoreductase subunit E
    Primary source
    ECOCYC:EG12086
    Locus tag
    b2285
    See related
    ASAP:ABE-0007547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2279
    Summary
    NuoE is part of the soluble fragment of NADH dehydrogenase I, which represents the electron input part of the enzyme . [More information is available at EcoCyc: EG12086].
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    Genomic context

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    Sequence:
    NC_000913.3 (2401552..2402052, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADH:quinone oxidoreductase subunit I Neighboring gene NADH:quinone oxidoreductase subunit H Neighboring gene NADH:quinone oxidoreductase subunit G Neighboring gene NADH:quinone oxidoreductase subunit F Neighboring gene NADH:quinone oxidoreductase subunit CD Neighboring gene NADH:quinone oxidoreductase subunit B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Significance of [2Fe-2S] Cluster N1a for Electron Transfer and Assembly of Escherichia coli Respiratory Complex I. Dörner K, et al. Biochemistry, 2017 Jun 6. PMID 28509551
    2. Amino acid residues associated with cluster N3 in the NuoF subunit of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli. Velazquez I, et al. FEBS Lett, 2005 Jun 6. PMID 15922336
    3. Spin labeling of the Escherichia coli NADH ubiquinone oxidoreductase (complex I). Pohl T, et al. Biochim Biophys Acta, 2010 Dec. PMID 20959113
    4. FSscan: a mechanism-based program to identify +1 ribosomal frameshift hotspots. Liao PY, et al. Nucleic Acids Res, 2009 Nov. PMID 19783813, Free PMC Article
    5. Metabolic regulation analysis of icd-gene knockout Escherichia coli based on 2D electrophoresis with MALDI-TOF mass spectrometry and enzyme activity measurements. Kabir MM, et al. Appl Microbiol Biotechnol, 2004 Jul. PMID 15221231

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study determined the distance between a MTSL labeled complex I variant and the bound quinone by continuous-wave (cw) EPR allowing an inference on the location of the quinone binding site.
      Title: Spin labeling of the Escherichia coli NADH ubiquinone oxidoreductase (complex I).
    2. N-terminus verified by Edman degradation on complete protein
      Title: Adenosine diphosphate sugar pyrophosphatase prevents glycogen biosynthesis in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to NADH dehydrogenase (ubiquinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to NADH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in respiratory electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADH dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH:quinone oxidoreductase subunit E
    NP_416788.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2401552..2402052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416788.1 NADH:quinone oxidoreductase subunit E [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416788.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AI56, A0A6C9QG37
      Conserved Domains (1) summary
      PRK07539
      Location:14 → 166
      PRK07539; NADH-quinone oxidoreductase subunit NuoE
    Nucleotide Protein
    Heading Accession and Version

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