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    purM phosphoribosylformylglycinamide cyclo-ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946975, updated on 3-Dec-2024

    Summary

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    Official Symbol
    purM
    Official Full Name
    phosphoribosylformylglycinamide cyclo-ligase
    Primary source
    ECOCYC:EG10798
    Locus tag
    b2499
    See related
    ASAP:ABE-0008230
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2495; purG; purI
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    Genomic context

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    Sequence:
    NC_000913.3 (2621197..2622234)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene uracil:H(+) symporter UraA Neighboring gene uracil phosphoribosyltransferase Neighboring gene phosphoribosylglycinamide formyltransferase 1 Neighboring gene polyphosphate kinase Neighboring gene exopolyphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of aminoimidazole ribonucleotide synthetase from Escherichia coli. Schrimsher JL, et al. Biochemistry, 1986 Jul 29. PMID 3530323
    2. Nucleotide sequence of the purM gene encoding 5'-phosphoribosyl-5-aminoimidazole synthetase of Escherichia coli K12. Smith JM, et al. J Biol Chem, 1986 Aug 15. PMID 3015935
    3. Identification of the enzymatic reactions encoded by the purG and purI genes of Escherichia coli. Houlberg U, et al. J Bacteriol, 1983 Jun. PMID 6343356, Free PMC Article
    4. Characterization of the upp gene encoding uracil phosphoribosyltransferase of Escherichia coli K12. Andersen PS, et al. Eur J Biochem, 1992 Feb 15. PMID 1371255
    5. P-BOSS: a new filtering method for treasure hunting in metabolomics. Morohashi M, et al. J Chromatogr A, 2007 Aug 3. PMID 17400234

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylamine-glycine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylformylglycinamidine cyclo-ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoribosylformylglycinamide cyclo-ligase
    NP_416994.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2621197..2622234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416994.1 phosphoribosylformylglycinamide cyclo-ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416994.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TWM0
      Conserved Domains (1) summary
      PRK05385
      Location:7 → 333
      PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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