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    nanQ N-acetylneuraminate anomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947750, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nanQ
    Official Full Name
    N-acetylneuraminate anomerase
    Primary source
    ECOCYC:G7675
    Locus tag
    b3221
    See related
    ASAP:ABE-0010569
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3210; yhcH
    Summary
    EbgC is a distant homolog of YiaL, YhcH and YjgK; all four match pfam PF04074. otherPDB (H. influenzae): [More information is available at EcoGene: EG12814]. yhcH may be part of the sialic acid catabolic operon, although it is not required for growth on N-acetylmannosamine . [More information is available at EcoCyc: G7675].
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    Genomic context

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    Sequence:
    NC_000913.3 (3369014..3369478, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DUF1120 domain-containing protein YhcF Neighboring gene DUF1016 domain-containing protein YhcG Neighboring gene N-acetylmannosamine kinase Neighboring gene putative N-acetylmannosamine-6-phosphate 2-epimerase Neighboring gene N-acetylneuraminate:H(+) symporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complete nucleotide sequence of the E. coli N-acetylneuraminate lyase. Ohta Y, et al. Nucleic Acids Res, 1985 Dec 20. PMID 3909108, Free PMC Article
    2. Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli. Kalivoda KA, et al. J Bacteriol, 2003 Aug. PMID 12897000, Free PMC Article
    3. Diversity of microbial sialic acid metabolism. Vimr ER, et al. Microbiol Mol Biol Rev, 2004 Mar. PMID 15007099, Free PMC Article
    4. Identification and functional analysis of 'hypothetical' genes expressed in Haemophilus influenzae. Kolker E, et al. Nucleic Acids Res, 2004. PMID 15121896, Free PMC Article
    5. Convergent pathways for utilization of the amino sugars N-acetylglucosamine, N-acetylmannosamine, and N-acetylneuraminic acid by Escherichia coli. Plumbridge J, et al. J Bacteriol, 1999 Jan. PMID 9864311, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in N-acetylneuraminate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylneuraminate anomerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3369014..3369478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417688.1 N-acetylneuraminate anomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417688.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376D101, A0A8S7ED01, A0A8T5Y790
      Conserved Domains (1) summary
      TIGR00022
      Location:1 → 140
      TIGR00022; YhcH/YjgK/YiaL family protein
    Nucleotide Protein
    Heading Accession and Version

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