envZ sensor histidine kinase EnvZ [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: envZ
Official Full Name: sensor histidine kinase EnvZ
Primary source: ECOCYC:EG10269
Locus tag: b3404
See related: ASAP:ABE-0011108
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3391; ompB; perA; tpo
Summary: The cogate response regulator for EnvZ is OmpR. [More information is available at EcoGene: EG10269]. The EnvZ protein can exist in two alternative conformational states, a high osmolarity form and a low osmolarity form. [More information is available at EcoCyc: EG10269].
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Genomic context

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Sequence:: NC_000913.3 (3534516..3535868, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The two-component system histidine kinase EnvZ contributes to Avian pathogenic Escherichia coli pathogenicity by regulating biofilm formation and stress responses.
Title: The two-component system histidine kinase EnvZ contributes to Avian pathogenic Escherichia coli pathogenicity by regulating biofilm formation and stress responses.
Roles of the EnvZ/OmpR Two-Component System and Porins in Iron Acquisition in Escherichia coli.
Title: Roles of the EnvZ/OmpR Two-Component System and Porins in Iron Acquisition in Escherichia coli.
Reduced expression of the porin master regulator OmpR and its cognate kinase EnvZ is used as a resistance strategy by E. coli cells to survive ammonia-mediated antibiosis
Title: Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species.
findings reveal an unknown OmpC-dependent mechanism of ethanol tolerance in a manner of EnvZ/OmpR regulation.
Title: Identification of ethanol tolerant outer membrane proteome reveals OmpC-dependent mechanism in a manner of EnvZ/OmpR regulation in Escherichia coli.
study also reveals that polyP-dependent stalling has little effect on EnvZ levels. Hence, both polyP motifs in EnvZ are primarily involved in protein-protein interaction.
Title: The role of polyproline motifs in the histidine kinase EnvZ.
A library of single-Cys-containing EnvZ proteins was used to show that the major TM1-TM1' interface falls along a single surface consisting of residue positions 19, 23, 26, 30 and 34. Cys substitutions in the N- and C-terminal regions of TM1 change EnvZ signal output. Core residues in TM1 cause TM1 dimerisation and maintenance of steady-state signal output. Extracellular osmolarity does not rearrange TM1-TM1' interfaces.
Title: Identification of transmembrane helix 1 (TM1) surfaces important for EnvZ dimerisation and signal output.
Cytoplasmic sensing by the inner membrane histidine kinase EnvZ
Title: Cytoplasmic sensing by the inner membrane histidine kinase EnvZ.
structure shows an asymmetric histidine kinase dimer where one subunit is caught performing the autophosphorylation reaction
Title: Visualizing autophosphorylation in histidine kinases.
There is a differential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues.
Title: Differential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues.
Both the E. coli MG1655 and E. coli Nissle 1917 strains containing envZP41L produced more phosphorylated OmpR than their parents.
Title: An Escherichia coli Nissle 1917 missense mutant colonizes the streptomycin-treated mouse intestine better than the wild type but is not a better probiotic.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphorelay sensor kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorelay sensor kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphorelay sensor kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorelay signal transduction system	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in outer membrane-bounded periplasmic space	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info