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    feoB Fe(2(+)) transporter FeoB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947919, updated on 17-Dec-2024

    Summary

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    Official Symbol
    feoB
    Official Full Name
    Fe(2(+)) transporter FeoB
    Primary source
    ECOCYC:EG12102
    Locus tag
    b3409
    See related
    ASAP:ABE-0011126
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3396
    Summary
    FeoB GTPase actvity is required for ferrous iron uptake; it slowly hydrolyzes its bound GTP. [More information is available at EcoGene: EG12102]. FeoB is a ferrous iron uptake system belonging to the Ferrous Iron Uptake (FeoB) transporter family . [More information is available at EcoCyc: EG12102].
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    Genomic context

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    Sequence:
    NC_000913.3 (3540407..3542728)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative RNA-binding protein YhgF Neighboring gene ferrous iron transport protein A Neighboring gene ferrous iron transport protein FeoC Neighboring gene recombination-promoting nuclease RpnA Neighboring gene pimeloyl-acyl carrier protein methyl ester esterase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release. Guilfoyle AP, et al. Biosci Rep, 2014 Dec 12. PMID 25374115, Free PMC Article
    2. Structural basis of GDP release and gating in G protein coupled Fe2+ transport. Guilfoyle A, et al. EMBO J, 2009 Sep 2. PMID 19629046, Free PMC Article
    3. Escherichia coli K-12 ferrous iron uptake mutants are impaired in their ability to colonize the mouse intestine. Stojiljkovic I, et al. FEMS Microbiol Lett, 1993 Mar 15. PMID 8472918
    4. Bacterial iron homeostasis. Andrews SC, et al. FEMS Microbiol Rev, 2003 Jun. PMID 12829269
    5. Iron transport in Escherichia coli: all has not been said and done. Grass G. Biometals, 2006 Apr. PMID 16718601

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that several of the residues in the G5 loop of the FeoB GTPase domain have an important role in the intrinsic affinity and release of GDP.
      Title: Exploring the correlation between the sequence composition of the nucleotide binding G5 loop of the FeoB GTPase domain (NFeoB) and intrinsic rate of GDP release.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferrous iron transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within iron ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within iron ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fe(2(+)) transporter FeoB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3540407..3542728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417868.1 Fe(2(+)) transporter FeoB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417868.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377D8V8, A0A8S7TAD7
      Conserved Domains (1) summary
      PRK09554
      Location:1 → 773
      feoB; Fe(2+) transporter permease subunit FeoB
    Nucleotide Protein
    Heading Accession and Version

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