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    nikB Ni(2(+)) ABC transporter membrane subunit NikB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947986, updated on 17-Dec-2024

    Summary

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    Official Symbol
    nikB
    Official Full Name
    Ni(2(+)) ABC transporter membrane subunit NikB
    Primary source
    ECOCYC:EG12076
    Locus tag
    b3477
    See related
    ASAP:ABE-0011356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3461; hydC; hydD
    Summary
    Mutants display nickel-remediated formate hydrogen-lyase, hydrogenase, and hydrogenase-related fumarase defects. [More information is available at EcoGene: EG12076]. The NikABCDE ATP-dependent nickel (II) uptake system is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG12076].
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    Genomic context

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    Sequence:
    NC_000913.3 (3615241..3616185)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene holo-[acyl carrier protein] synthase 2 Neighboring gene Ni(2(+)) ABC transporter periplasmic binding protein Neighboring gene Ni(2(+)) ABC transporter membrane subunit NikC Neighboring gene Ni(2(+)) ABC transporter ATP binding subunit NikD Neighboring gene Ni(2(+)) ABC transporter ATP binding subunit NikE Neighboring gene DNA-binding transcriptional repressor NikR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The hydC region contains a multi-cistronic operon (nik) involved in nickel transport in Escherichia coli. Wu LF, et al. Gene, 1991 Oct 30. PMID 1743519
    2. Purification and characterization of the periplasmic nickel-binding protein NikA of Escherichia coli K12. de Pina K, et al. Eur J Biochem, 1995 Feb 1. PMID 7867647
    3. Identification of Ni-(L-His)₂ as a substrate for NikABCDE-dependent nickel uptake in Escherichia coli. Chivers PT, et al. Metallomics, 2012 Oct. PMID 22885853
    4. Crystallographic and spectroscopic evidence for high affinity binding of FeEDTA(H2O)- to the periplasmic nickel transporter NikA. Cherrier MV, et al. J Am Chem Soc, 2005 Jul 20. PMID 16011372
    5. Nickel transport systems in microorganisms. Eitinger T, et al. Arch Microbiol, 2000 Jan. PMID 10648098

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables dipeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nickel cation binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nickel cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nickel cation transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dipeptide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nickel cation import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nickel cation import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nickel cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nickel cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ni(2(+)) ABC transporter membrane subunit NikB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3615241..3616185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417934.1 Ni(2(+)) ABC transporter membrane subunit NikB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417934.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FGR0
      Conserved Domains (1) summary
      PRK10352
      Location:1 → 314
      PRK10352; nickel transporter permease NikB; Provisional
    Nucleotide Protein
    Heading Accession and Version

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