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    waaY lipopolysaccharide core heptose (II) kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948145, updated on 3-Dec-2024

    Summary

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    Official Symbol
    waaY
    Official Full Name
    lipopolysaccharide core heptose (II) kinase
    Primary source
    ECOCYC:EG11425
    Locus tag
    b3625
    See related
    ASAP:ABE-0011856
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3615; rfaY
    Summary
    The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11425].
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    Genomic context

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    Sequence:
    NC_000913.3 (3800267..3800965, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative ADP-heptose:LPS heptosyltransferase 4 Neighboring gene lipopolysaccharide core biosynthesis protein WaaZ Neighboring gene UDP-glucose:(glucosyl)LPS alpha-1,2-glucosyltransferase Neighboring gene UDP-D-glucose:(glucosyl)LPS alpha-1,3-glucosyltransferase Neighboring gene UDP-D-galactose:(glucosyl)lipopolysaccharide-1,6-D-galactosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipopolysaccharide Phosphorylation by the WaaY Kinase Affects the Susceptibility of Escherichia coli to the Human Antimicrobial Peptide LL-37. Bociek K, et al. J Biol Chem, 2015 Aug 7. PMID 26100635, Free PMC Article
    2. Mutation of the lipopolysaccharide core glycosyltransferase encoded by waaG destabilizes the outer membrane of Escherichia coli by interfering with core phosphorylation. Yethon JA, et al. J Bacteriol, 2000 Oct. PMID 10986272, Free PMC Article
    3. SoxRS-mediated lipopolysaccharide modification enhances resistance against multiple drugs in Escherichia coli. Lee JH, et al. J Bacteriol, 2009 Jul. PMID 19376854, Free PMC Article
    4. Role of the rfaG and rfaP genes in determining the lipopolysaccharide core structure and cell surface properties of Escherichia coli K-12. Parker CT, et al. J Bacteriol, 1992 Apr. PMID 1348243, Free PMC Article
    5. Role of Escherichia coli K-12 rfa genes and the rfp gene of Shigella dysenteriae 1 in generation of lipopolysaccharide core heterogeneity and attachment of O antigen. Klena JD, et al. J Bacteriol, 1992 Nov. PMID 1385388, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lipopolysaccharide phosphorylation by the WaaY kinase affects the susceptibility of Escherichia coli to the human antimicrobial peptide LL-37.
      Title: Lipopolysaccharide Phosphorylation by the WaaY Kinase Affects the Susceptibility of Escherichia coli to the Human Antimicrobial Peptide LL-37.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    lipopolysaccharide core heptose (II) kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3800267..3800965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418082.1 lipopolysaccharide core heptose (II) kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418082.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7UCF9
      Conserved Domains (1) summary
      pfam06176
      Location:1 → 229
      WaaY; Lipopolysaccharide core biosynthesis protein (WaaY)
    Nucleotide Protein
    Heading Accession and Version

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