lysC aspartate kinase III [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: lysC
Official Full Name: aspartate kinase III
Primary source: ECOCYC:EG10550
Locus tag: b4024
See related: ASAP:ABE-0013156
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: apk; ECK4016
Summary: Mutations in an L box riboswitch regulated by free lysine is in the lysC mRNA 5' UTR confer resistance to S-(2-aminoethyl)-L-cysteine (AEC) by derepressing lysine biosynthesis and outcompeting AEC inhibition of LysRS (Ataide, 2007). [More information is available at EcoGene: EG10550]. Aspartokinase III (LysC) is one of three aspartokinase activities catalyzing the first step in the biosynthesis of lysine and homoserine, and indirectly methionine and threonine. [More information is available at EcoCyc: EG10550].
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NC_000913.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aspartate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartate kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in homoserine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homoserine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lysine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lysine biosynthetic process via diaminopimelate	IDA Inferred from Direct Assay more info	PubMed
involved_in lysine biosynthetic process via diaminopimelate	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_418448.1

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The following sections contain reference sequences that belong to a specific genome build. Explain