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    cutA copper binding protein CutA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948660, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cutA
    Official Full Name
    copper binding protein CutA
    Primary source
    ECOCYC:EG12177
    Locus tag
    b4137
    See related
    ASAP:ABE-0013544
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cutA1; ECK4131
    Summary
    CutA is a copper-binding protein that is also required for copper tolerance. [More information is available at EcoCyc: EG12177].
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    Genomic context

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    Sequence:
    NC_000913.3 (4365018..4365356, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Phe Neighboring gene putative DNA-binding transcriptional regulator YjdC Neighboring gene thiol-disulfide exchange protein DsbD Neighboring gene C4-dicarboxylate transporter DcuA Neighboring gene ncRNA Neighboring gene aspartate ammonia-lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Remarkable improvement in the heat stability of CutA1 from Escherichia coli by rational protein design. Matsuura Y, et al. J Biochem, 2010 Oct. PMID 20639520
    2. Protonless 13C direct detection NMR: characterization of the 37 kDa trimeric protein CutA1. Bertini I, et al. Proteins, 2008 Mar. PMID 17847095
    3. Hyper-thermostability of CutA1 protein, with a denaturation temperature of nearly 150 degrees C. Tanaka T, et al. FEBS Lett, 2006 Jul 24. PMID 16831434
    4. A mutation blocking the formation of membrane or periplasmic endogenous and exogenous c-type cytochromes in Escherichia coli permits the cytoplasmic formation of Hydrogenobacter thermophilus holo cytochrome c552. Sambongi Y, et al. FEBS Lett, 1994 May 16. PMID 8187885
    5. A reassessment of the range of c-type cytochromes synthesized by Escherichia coli K-12. Iobbi-Nivol C, et al. FEMS Microbiol Lett, 1994 Jun 1. PMID 8039676

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the stability of Escherichia coli CutA1 is remarkably improved by slight substitutions, and that remarkable improvements in stability can be quantitatively explained based on the newly solved native structure.
      Title: Remarkable improvement in the heat stability of CutA1 from Escherichia coli by rational protein design.
    2. structural characterization of CutA1 in solution by NMR
      Title: Protonless 13C direct detection NMR: characterization of the 37 kDa trimeric protein CutA1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to metal ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    copper binding protein CutA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4365018..4365356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418560.1 copper binding protein CutA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418560.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3HXS3, A0A1X3J6U0, A0A1X3J927
      Conserved Domains (1) summary
      PRK10645
      Location:1 → 112
      PRK10645; divalent cation tolerance protein CutA
    Nucleotide Protein
    Heading Accession and Version

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