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    cpdB 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948729, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cpdB
    Official Full Name
    2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
    Primary source
    ECOCYC:EG10160
    Locus tag
    b4213
    See related
    ASAP:ABE-0013782
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4209
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    Genomic context

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    Sequence:
    NC_000913.3 (4434622..4436565, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene NAD(P)H:quinone oxidoreductase Neighboring gene putative transcriptional regulator YtfH Neighboring gene 3'(2'),5'-bisphosphate nucleotidase Neighboring gene protein YtfI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of Escherichia coli mutants (cpdB) deficient in periplasmic 2':3'-cyclic phosphodiesterase and genetic mapping of the cpdB locus. Beacham IR, et al. J Gen Microbiol, 1980 Jul. PMID 6251162
    2. Transcription and regulation of the cpdB gene in Escherichia coli K12 and Salmonella typhimurium LT2: evidence for modulation of constitutive promoters by cyclic AMP-CRP complex. Liu J, et al. Mol Gen Genet, 1990 Jun. PMID 2172762
    3. Localization of the Escherichia coli amtA gene to 95.8 minutes. Jayakumar A, et al. J Bacteriol, 1991 Mar. PMID 1999381, Free PMC Article
    4. Release of periplasmic enzymes from Escherichia coli by penicillin-ethylenediaminetetraacetate treatment. Ananthaswamy HN. J Bacteriol, 1977 Aug. PMID 195932, Free PMC Article
    5. Comparison of the large-scale periplasmic proteomes of the Escherichia coli K-12 and B strains. Han MJ, et al. J Biosci Bioeng, 2014 Apr. PMID 24140104

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 3'-nucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3'-nucleotidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
    NP_418634.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4434622..4436565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418634.1 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418634.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GK32, A0A8S7ECV0
      Conserved Domains (1) summary
      PRK09420
      Location:1 → 647
      cpdB; bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
    Nucleotide Protein
    Heading Accession and Version

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