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    chpB endoribonuclease toxin ChpB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948747, updated on 17-Dec-2024

    Summary

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    Official Symbol
    chpB
    Official Full Name
    endoribonuclease toxin ChpB
    Primary source
    ECOCYC:EG12096
    Locus tag
    b4225
    See related
    ASAP:ABE-0013822
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    chpBK; ECK4221; yjfE
    Summary
    ChpB(ChpBK) is a sequence-specific (ACY) endoribonuclease. [More information is available at EcoGene: EG12096]. ChpB is the toxin component of the ChpB-ChpS toxin-antitoxin system. [More information is available at EcoCyc: EG12096].
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    Genomic context

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    Sequence:
    NC_000913.3 (4448692..4449042)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene translocation and assembly module subunit TamA Neighboring gene translocation and assembly module subunit TamB Neighboring gene gamma-glutamylamine cyclotransferase family protein YtfP Neighboring gene ChpS antitoxin of the ChpB-ChpS toxin-antitoxin system Neighboring gene inorganic pyrophosphatase Neighboring gene galactofuranose ABC transporter periplasmic binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Use of genetically engineered phage to deliver antimicrobial agents to bacteria: an alternative therapy for treatment of bacterial infections. Westwater C, et al. Antimicrob Agents Chemother, 2003 Apr. PMID 12654662, Free PMC Article
    2. Cloning and characterization of the gene encoding inorganic pyrophosphatase of Escherichia coli K-12. Lahti R, et al. J Bacteriol, 1988 Dec. PMID 2848015, Free PMC Article
    3. Structural analysis of the ileR locus of Escherichia coli K12. Weiss DL, et al. J Biol Chem, 1986 Jul 25. PMID 3525538
    4. Mapping and disruption of the chpB locus in Escherichia coli. Masuda Y, et al. J Bacteriol, 1994 Sep. PMID 8083180, Free PMC Article
    5. Functional interactions between chpB and parD, two homologous conditional killer systems found in the Escherichia coli chromosome and in plasmid R1. Santos Sierra S, et al. FEMS Microbiol Lett, 1998 Nov 1. PMID 9812362

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the signaling molecule extracellular death factor significantly amplifies the endoribonucleolytic activities of both MazF and ChpBK.
      Title: The Escherichia coli extracellular death factor EDF induces the endoribonucleolytic activities of the toxins MazF and ChpBK.
    2. ChpBK is an mRNA interferase from Escherichia coli
      Title: Characterization of ChpBK, an mRNA interferase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity, producing 5'-phosphomonoesters IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mRNA stability IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in single-species biofilm formation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endoribonuclease toxin ChpB
    NP_418646.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4448692..4449042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418646.1 endoribonuclease toxin ChpB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418646.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EMN9
      Conserved Domains (1) summary
      PRK09812
      Location:1 → 116
      PRK09812; type II toxin-antitoxin system ChpB family toxin
    Nucleotide Protein
    Heading Accession and Version

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