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    can carbonic anhydrase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944832, updated on 3-Dec-2024

    Summary

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    Official Symbol
    can
    Official Full Name
    carbonic anhydrase 2
    Primary source
    ECOCYC:EG12319
    Locus tag
    b0126
    See related
    ASAP:ABE-0000442
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0125; yadF
    Summary
    can forms a synthetic lethal with cynT, rescued by high CO2. [More information is available at EcoGene: EG12319]. Escherichia coli encodes two carbonic anhydrases, Can (carbonic anhydrase 2) and CynT (carbonic anhydrase 1). [More information is available at EcoCyc: EG12319].
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    Genomic context

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    Sequence:
    NC_000913.3 (142008..142670, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene quinoprotein glucose dehydrogenase Neighboring gene hypoxanthine phosphoribosyltransferase Neighboring gene putative ABC transporter ATP-binding protein YadG Neighboring gene putative ABC transporter membrane subunit YadH Neighboring gene putative PTS enzyme IIA component YadI

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of E. coli beta-carbonic anhydrase, an enzyme with an unusual pH-dependent activity. Cronk JD, et al. Protein Sci, 2001 May. PMID 11316870, Free PMC Article
    2. Cloning, crystallization and preliminary characterization of a beta-carbonic anhydrase from Escherichia coli. Cronk JD, et al. Acta Crystallogr D Biol Crystallogr, 2000 Sep. PMID 10957638
    3. Identification of a novel noncatalytic bicarbonate binding site in eubacterial beta-carbonic anhydrase. Cronk JD, et al. Biochemistry, 2006 Apr 11. PMID 16584170
    4. Bacterial carbonic anhydrases. Kozliak EI, et al. EXS, 2000. PMID 11268536
    5. Indispensability of the Escherichia coli carbonic anhydrases YadF and CynT in cell proliferation at a low CO2 partial pressure. Hashimoto M, et al. Biosci Biotechnol Biochem, 2003 Apr. PMID 12784642

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbonate dehydratase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbon utilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbon utilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carbonic anhydrase 2
    NP_414668.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      142008..142670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414668.1 carbonic anhydrase 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414668.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3R0MWD7
      Conserved Domains (1) summary
      PRK10437
      Location:1 → 220
      PRK10437; carbonic anhydrase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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