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    folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948792, updated on 3-Dec-2024

    Summary

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    Official Symbol
    folK
    Official Full Name
    2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
    Primary source
    ECOCYC:EG11374
    Locus tag
    b0142
    See related
    ASAP:ABE-0000491
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0141
    Summary
    Reduced folate cofactors are required for the syntheses of various essential cell nutrients. [More information is available at EcoCyc: EG11374].
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    Genomic context

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    Sequence:
    NC_000913.3 (157253..157732, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial chaperone YadV Neighboring gene putative fimbrial protein YadN Neighboring gene poly(A) polymerase I Neighboring gene glutamyl-Q tRNA(Asp) synthetase Neighboring gene RNA polymerase-binding transcription factor DksA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics of the conformational transitions in the assembling of the Michaelis complex of a bisubstrate enzyme: a (15)N relaxation study of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Lescop E, et al. Biochemistry, 2009 Jan 20. PMID 19108643
    2. The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid. Richey DP, et al. J Biol Chem, 1969 Mar 25. PMID 4304228
    3. Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents. Xiao B, et al. Structure, 1999 May. PMID 10378268
    4. 1H, 13C and 15N resonance assignments of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase and its complex with MgAMPPCP. Shi G, et al. J Biomol NMR, 1999 Jun. PMID 10427747
    5. 2.0 A X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue. Stammers DK, et al. FEBS Lett, 1999 Jul 30. PMID 10452528

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Purification and partial characterization of 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase and 7,8-dihydropteroate synthase from Escherichia coli MC4100.
    2. biophysical analysis of conformation and dynamics of the Escherichia coli HPPK apo-enzyme and its binary complex with MgATP
      Title: Loop conformation and dynamics of the Escherichia coli HPPK apo-enzyme and its binary complex with MgATP.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in folic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
    NP_414684.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      157253..157732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414684.1 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414684.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MM44
      Conserved Domains (1) summary
      PRK10239
      Location:1 → 159
      PRK10239; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
    Nucleotide Protein
    Heading Accession and Version

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