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    fhuC iron(III) hydroxamate ABC transporter ATP binding subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945250, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fhuC
    Official Full Name
    iron(III) hydroxamate ABC transporter ATP binding subunit
    Primary source
    ECOCYC:EG10304
    Locus tag
    b0151
    See related
    ASAP:ABE-0000522
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0150
    Summary
    fhuC mutants are albomycin resistant. [More information is available at EcoGene: EG10304]. The FhuBCD ATP-dependent iron (III) hydroxamate transporter is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10304].
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    Genomic context

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    Sequence:
    NC_000913.3 (169778..170575)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PBP1Bgamma;peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcB Neighboring gene ferrichrome outer membrane transporter/phage receptor Neighboring gene iron(III) hydroxamate ABC transporter periplasmic binding protein Neighboring gene iron(III) hydroxamate ABC transporter membrane subunit Neighboring gene glutamate-1-semialdehyde 2,1-aminomutase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM reveals unique structural features of the FhuCDB Escherichia coli ferrichrome importer. Hu W, et al. Commun Biol, 2021 Dec 9. PMID 34887516, Free PMC Article
    2. Conserved amino acids in the N- and C-terminal domains of integral membrane transporter FhuB define sites important for intra- and intermolecular interactions. Böhm B, et al. Mol Microbiol, 1996 Apr. PMID 8861219
    3. ATP-dependent ferric hydroxamate transport system in Escherichia coli: periplasmic FhuD interacts with a periplasmic and with a transmembrane/cytoplasmic region of the integral membrane protein FhuB, as revealed by competitive peptide mapping. Mademidis A, et al. Mol Microbiol, 1997 Dec. PMID 9426146
    4. fhuC and fhuD genes for iron (III)-ferrichrome transport into Escherichia coli K-12. Coulton JW, et al. J Bacteriol, 1987 Aug. PMID 3301821, Free PMC Article
    5. Iron(III) hydroxamate transport across the cytoplasmic membrane of Escherichia coli. Köster W. Biol Met, 1991. PMID 1830209

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ABC-type ferric hydroxamate transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ABC-type ferric hydroxamate transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferric iron transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables siderophore uptake transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ferric-hydroxamate import into cell EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in iron ion import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    iron(III) hydroxamate ABC transporter ATP binding subunit
    NP_414693.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      169778..170575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414693.1 iron(III) hydroxamate ABC transporter ATP binding subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414693.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FR97
      Conserved Domains (1) summary
      PRK10575
      Location:1 → 265
      PRK10575; Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC
    Nucleotide Protein
    Heading Accession and Version

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