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    lacA galactoside O-acetyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945674, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lacA
    Official Full Name
    galactoside O-acetyltransferase
    Primary source
    ECOCYC:EG10524
    Locus tag
    b0342
    See related
    ASAP:ABE-0001177
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0339
    Summary
    LacA contains 8 hexapeptide repeats. [More information is available at EcoGene: EG10524]. Early work done on the protein identified it as a homodimer, however recent work has shown it to be a homotrimer. [More information is available at EcoCyc: EG10524].
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    Genomic context

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    Sequence:
    NC_000913.3 (361249..361860, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cyanase Neighboring gene cyanate transporter Neighboring gene lactose permease Neighboring gene beta-galactosidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification of thiogalactoside transacetylase by affinity chromatography. Zabin I, et al. Anal Biochem, 1984 Feb. PMID 6372544
    2. Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification. Andrews KJ, et al. J Bacteriol, 1976 Oct. PMID 789355, Free PMC Article
    3. DNA sequence of the lactose operon: the lacA gene and the transcriptional termination region. Hediger MA, et al. Proc Natl Acad Sci U S A, 1985 Oct. PMID 3901000, Free PMC Article
    4. The amino acid sequence of thiogalactoside transacetylase of Escherichia coli. Fowler AV, et al. Biochimie, 1985 Jan. PMID 3922433
    5. lac Thiogalactoside transacetylase of Escherichia coli K-12 and ML. Fried VA. J Bacteriol, 1980 Jul. PMID 6995445, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: The amino acid sequence of thiogalactoside transacetylase of Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactoside O-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactoside O-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactoside O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lactose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    galactoside O-acetyltransferase
    NP_414876.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      361249..361860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414876.1 galactoside O-acetyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414876.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAQ1T753
      Conserved Domains (1) summary
      PRK09527
      Location:1 → 203
      lacA; galactoside O-acetyltransferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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