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    sbmA peptide antibiotic/peptide nucleic acid transporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946884, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sbmA
    Official Full Name
    peptide antibiotic/peptide nucleic acid transporter
    Primary source
    ECOCYC:EG10928
    Locus tag
    b0377
    See related
    ASAP:ABE-0001297
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0372
    Summary
    The sbmA gene product has been shown through deletion, mutation and complementation studies to code for the specific inner-membrane transport protein for Microcin 25 (Mcc25). [More information is available at EcoCyc: EG10928].
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    Genomic context

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    Sequence:
    NC_000913.3 (396639..397859)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative DNA-binding transcriptional regulator IprA Neighboring gene peptidoglycan DD-carboxypeptidase/peptidoglycan DD-endopeptidase Neighboring gene surface-exposed outer membrane lipoprotein Neighboring gene DUF2755 domain-containing inner membrane protein YaiY

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of SbmA, a bacterial inner membrane transporter required for importing the antimicrobial peptide Bac7(1-35). Runti G, et al. J Bacteriol, 2013 Dec. PMID 24078610, Free PMC Article
    2. Identification, mapping, cloning and characterization of a gene (sbmA) required for microcin B17 action on Escherichia coli K12. Laviña M, et al. J Gen Microbiol, 1986 Jun. PMID 3543211
    3. Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor. Yorgey P, et al. Proc Natl Acad Sci U S A, 1994 May 10. PMID 8183941, Free PMC Article
    4. Genetic analysis of the Sinorhizobium meliloti BacA protein: differential effects of mutations on phenotypes. LeVier K, et al. J Bacteriol, 2001 Nov. PMID 11591690, Free PMC Article
    5. Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides. Mattiuzzo M, et al. Mol Microbiol, 2007 Oct. PMID 17725560

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The yjiL-mdtM gene cluster mediates the antibacterial activity of proline-rich antimicrobial peptides overcoming Escherichia coli resistance induced by the missing SbmA transporter system.
      Title: Influence of the yjiL-mdtM Gene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System.
    2. SbmA upregulation in a tolC mutant context was abolished in an rpoE-null strain.
      Title: The tolC locus affects the expression of sbmA through σE activity increase.
    3. Data show that inactivation of sbmA alone partially inhibited high-level tetracycline resistance and the addition of an sbmA mutation to a tolC::Tn10 mutant exacerbates this phenotype.
      Title: A combination of sbmA and tolC mutations in Escherichia coli K-12 Tn10-carrying strains results in hypersusceptibility to tetracycline.
    4. SbmA, is necessary for the transport of, and for susceptibility to, proline-rich antimicrobial peptides of eukaryotic origin.
      Title: Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microcin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables secondary active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within microcin B17 transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microcin transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within microcin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peptide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptide transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptide antibiotic/peptide nucleic acid transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      396639..397859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414911.1 peptide antibiotic/peptide nucleic acid transporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414911.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7L7E9W0
      Conserved Domains (1) summary
      PRK11098
      Location:1 → 406
      PRK11098; peptide antibiotic transporter SbmA
    Nucleotide Protein
    Heading Accession and Version

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