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    selU tRNA 2-selenouridine synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947063, updated on 3-Dec-2024

    Summary

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    Official Symbol
    selU
    Official Full Name
    tRNA 2-selenouridine synthase
    Primary source
    ECOCYC:EG11768
    Locus tag
    b0503
    See related
    ASAP:ABE-0001740
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0496; mnmH; ybbB
    Summary
    SelU(YbbB) has a rhodanese domain. [More information is available at EcoGene: EG11768]. The ybbB gene encodes the tRNA 2-selenouridine synthase responsible for formation of the special selenium-containing wobble base of the three tRNAs tRNALys, tRNAGlu, and tRNAGln . [More information is available at EcoCyc: EG11768].
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    Genomic context

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    Sequence:
    NC_000913.3 (530132..531226, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene putative DNA-binding transcriptional regulator YlbG Neighboring gene DNA-binding transcriptional activator AllS Neighboring gene ureidoglycolate lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Escherichia coli tRNA 2-selenouridine synthase SelU selects its prenyl substrate to accomplish its enzymatic function. Szczupak P, et al. Bioorg Chem, 2022 May. PMID 35306417
    2. Escherichia coli tRNA 2-selenouridine synthase (SelU) converts S2U-RNA to Se2U-RNA via S-geranylated-intermediate. Sierant M, et al. FEBS Lett, 2018 Jul. PMID 29862510
    3. Discovery and biological characterization of geranylated RNA in bacteria. Dumelin CE, et al. Nat Chem Biol, 2012 Nov. PMID 22983156, Free PMC Article
    4. Functional diversity of the rhodanese homology domain: the Escherichia coli ybbB gene encodes a selenophosphate-dependent tRNA 2-selenouridine synthase. Wolfe MD, et al. J Biol Chem, 2004 Jan 16. PMID 14594807
    5. A purified selenophosphate-dependent enzyme from Salmonella typhimurium catalyzes the replacement of sulfur in 2-thiouridine residues in tRNAs with selenium. Veres Z, et al. Proc Natl Acad Sci U S A, 1994 Aug 16. PMID 7520175, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables tRNA 2-selenouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA 2-selenouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA 2-selenouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA seleno-modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA 2-selenouridine synthase
    NP_415036.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      530132..531226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415036.1 tRNA 2-selenouridine synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415036.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MYF5, A0AAI9MEZ8
      Conserved Domains (1) summary
      PRK11784
      Location:3 → 364
      PRK11784; tRNA 2-selenouridine synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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