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    entA 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945284, updated on 3-Dec-2024

    Summary

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    Official Symbol
    entA
    Official Full Name
    2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
    Primary source
    ECOCYC:EG10259
    Locus tag
    b0596
    See related
    ASAP:ABE-0002054
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0589
    Summary
    2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase catalyzes the formation of 2,3-dihydroxybenzoate (DHB), an intermediate in the enterobactin biosynthesis pathway. [More information is available at EcoCyc: EG10259].
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    Genomic context

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    Sequence:
    NC_000913.3 (628551..629297)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene isochorismate synthase EntC Neighboring gene 2,3-dihydroxybenzoate-AMP ligase Neighboring gene enterobactin synthase component B Neighboring gene proofreading thioesterase in enterobactin biosynthesis Neighboring gene pyruvate transporter CstA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli. Sundlov JA, et al. Acta Crystallogr D Biol Crystallogr, 2006 Jul. PMID 16790929
    2. Mechanistic studies on trans-2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (Ent A) in the biosynthesis of the iron chelator enterobactin. Sakaitani M, et al. Biochemistry, 1990 Jul 24. PMID 2144454
    3. Nucleotide sequence of the Escherichia coli entE gene. Staab JF, et al. FEMS Microbiol Lett, 1989 May. PMID 2525505
    4. Biosynthesis of the iron-transport compound enterochelin: mutants of Escherichia coli unable to synthesize 2,3-dihydroxybenzoate. Young IG, et al. J Bacteriol, 1971 Apr. PMID 4928016, Free PMC Article
    5. Role of enterobactin and intracellular iron in cell lethality during near-UV irradiation in Escherichia coli. Hoerter J, et al. Photochem Photobiol, 1996 Sep. PMID 8806229

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Nucleotide sequence of a cluster of Escherichia coli enterobactin biosynthesis genes: identification of entA and purification of its product 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in enterobactin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in enterobactin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within enterobactin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siderophore biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
    NP_415128.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      628551..629297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415128.1 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415128.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GKS4, A0A5B9AKU0, A0A8T5ZEM7
      Conserved Domains (1) summary
      PRK08220
      Location:1 → 248
      PRK08220; 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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