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    prs ribose-phosphate diphosphokinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945772, updated on 3-Dec-2024

    Summary

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    Official Symbol
    prs
    Official Full Name
    ribose-phosphate diphosphokinase
    Primary source
    ECOCYC:EG10774
    Locus tag
    b1207
    See related
    ASAP:ABE-0004054
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dnaR; ECK1195; prsA
    Summary
    HT_Cmplx20_Cyt: [More information is available at EcoGene: EG10774].
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    Genomic context

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    Sequence:
    NC_000913.3 (1260928..1261875, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene stress-induced protein Neighboring gene aerobic C4-dicarboxylate transporter DauA Neighboring gene 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase Neighboring gene outer membrane lipoprotein LolB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of E. coli PRPP synthetase. Zhou W, et al. BMC Struct Biol, 2019 Jan 15. PMID 30646888, Free PMC Article
    2. The defective phosphoribosyl diphosphate synthase in a temperature-sensitive prs-2 mutant of Escherichia coli is compensated by increased enzyme synthesis. Post DA, et al. Microbiology (Reading), 1996 Feb. PMID 8932709
    3. Suppression of thermosensitive initiation of DNA replication in a dnaR mutant of Escherichia coli by a rifampin resistance mutation in the rpoB gene. Sakakibara Y. J Bacteriol, 1995 Feb. PMID 7836308, Free PMC Article
    4. Inactivation of Escherichia coli phosphoribosylpyrophosphate synthetase by the 2',3'-dialdehyde derivative of ATP. Identification of active site lysines. Hilden I, et al. J Biol Chem, 1995 Sep 1. PMID 7657655
    5. Chromosomal location of the gene encoding phosphoribosylpyrophosphate synthetase in Escherichia coli. Hove-Jensen B. J Bacteriol, 1983 Apr. PMID 6300032, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Protein factors associated with the SsrA.SmpB tagging and ribosome rescue complex.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ADP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphate ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribose phosphate diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribose phosphate diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribose phosphate diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within 5-phosphoribose 1-diphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein hexamerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribose phosphate diphosphokinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribose-phosphate diphosphokinase
    NP_415725.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1260928..1261875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415725.1 ribose-phosphate diphosphokinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415725.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AN78
      Conserved Domains (1) summary
      PRK01259
      Location:4 → 314
      PRK01259; ribose-phosphate diphosphokinase
    Nucleotide Protein
    Heading Accession and Version

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