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    puuD gamma-glutamyl-gamma-aminobutyrate hydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945882, updated on 3-Dec-2024

    Summary

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    Official Symbol
    puuD
    Official Full Name
    gamma-glutamyl-gamma-aminobutyrate hydrolase
    Primary source
    ECOCYC:G6645
    Locus tag
    b1298
    See related
    ASAP:ABE-0004369
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1293; ycjL
    Summary
    C114 is the active site. [More information is available at EcoGene: EG13909]. PuuD was identified as the -glutamyl--aminobutyrate hydrolase in a putrescine utilization pathway. [More information is available at EcoCyc: G6645].
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    Genomic context

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    Sequence:
    NC_000913.3 (1361120..1361884)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putrescine:H(+) symporter PuuP Neighboring gene protein YmjE Neighboring gene glutamate-putrescine ligase Neighboring gene DNA-binding transcriptional repressor PuuR Neighboring gene gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12. Kurihara S, et al. FEMS Microbiol Lett, 2006 Mar. PMID 16499623
    2. A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. Kurihara S, et al. J Biol Chem, 2005 Feb 11. PMID 15590624
    3. Escherichia coli transcriptome dynamics during the transition from anaerobic to aerobic conditions. Partridge JD, et al. J Biol Chem, 2006 Sep 22. PMID 16857675
    4. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article
    5. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Arifuzzaman M, et al. Genome Res, 2006 May. PMID 16606699, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
    2. findings that the puuD-deficient strain accumulated gamma-glutamyl-gamma-aminobutyrate (gamma-Glu-GABA) and could not grow on putrescine as a sole nitrogen source indicate that PuuD is physiologically important as a gamma-Glu-GABA hydrolase
      Title: Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables gamma-glutamyl-gamma-aminobutyrate hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-glutamyl-gamma-aminobutyrate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gamma-glutamyl-gamma-aminobutyrate hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in polyamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in putrescine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within putrescine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-glutamyl-gamma-aminobutyrate hydrolase
    NP_415814.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1361120..1361884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415814.4 gamma-glutamyl-gamma-aminobutyrate hydrolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415814.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6UDL7
      Conserved Domains (1) summary
      PRK11366
      Location:1 → 254
      puuD; gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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