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    paaC phenylacetyl-CoA 1,2-epoxidase, structural subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945956, updated on 3-Dec-2024

    Summary

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    Official Symbol
    paaC
    Official Full Name
    phenylacetyl-CoA 1,2-epoxidase, structural subunit
    Primary source
    ECOCYC:G6711
    Locus tag
    b1390
    See related
    ASAP:ABE-0004653
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1387; ydbP
    Summary
    PaaABCDE is a multi-subunit oxygenase that hydroxylates phenylacetyl-CoA. [More information is available at EcoGene: EG13737]. PaaA, PaaB, PaaC, and PaaD are predicted to be subunits of a phenylacetate-CoA oxygenase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6711].
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    Genomic context

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    Sequence:
    NC_000913.3 (1455164..1455910)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit Neighboring gene phenylacetyl-CoA 1,2-epoxidase subunit B Neighboring gene phenylacetate degradation protein Neighboring gene phenylacetyl-CoA 1,2-epoxidase, reductase subunit Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex. Grishin AM, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Sep 1. PMID 20823522, Free PMC Article
    2. Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex. Grishin AM, et al. J Biol Chem, 2011 Mar 25. PMID 21247899, Free PMC Article
    3. Genetic characterization of the phenylacetyl-coenzyme A oxygenase from the aerobic phenylacetic acid degradation pathway of Escherichia coli. Fernández C, et al. Appl Environ Microbiol, 2006 Nov. PMID 16997993, Free PMC Article
    4. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
    5. Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Zhang N, et al. Proteomics, 2007 Feb. PMID 17309111

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PaaAC, which catalyzes the hydroxylation reaction, was purified and crystallized in the absence of a bound ligand as well as in complexes with CoA, 3-hydroxybutyryl-CoA, benzoyl-CoA and the true substrate phenylacetyl-CoA
      Title: Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phenylacetate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylacetate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phenylacetate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of phenylacetyl-CoA 1,2-epoxidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phenylacetyl-CoA 1,2-epoxidase, structural subunit
    NP_415908.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1455164..1455910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415908.1 phenylacetyl-CoA 1,2-epoxidase, structural subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415908.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C9AAD3
      Conserved Domains (1) summary
      TIGR02158
      Location:11 → 248
      PA_CoA_Oxy3; phenylacetate-CoA oxygenase, PaaI subunit
    Nucleotide Protein
    Heading Accession and Version

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