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    paaH 3-hydroxyadipyl-CoA dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945940, updated on 3-Dec-2024

    Summary

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    Official Symbol
    paaH
    Official Full Name
    3-hydroxyadipyl-CoA dehydrogenase
    Primary source
    ECOCYC:G6716
    Locus tag
    b1395
    See related
    ASAP:ABE-0004663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1392; hbdH; ydbU
    Summary
    paaH mutants accumulate 3-hydroxyadipate. [More information is available at EcoGene: EG13742]. PaaH is a putative 3-hydroxy-acyl-CoA dehydrogenase involved in phenylacetate catabolism . [More information is available at EcoCyc: G6716].
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    Genomic context

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    Sequence:
    NC_000913.3 (1459054..1460481)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetyl-CoA 1,2-epoxidase, reductase subunit Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase Neighboring gene putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) Neighboring gene phenylacetyl-CoA thioesterase Neighboring gene beta-ketoadipyl-CoA thiolase Neighboring gene phenylacetate-CoA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
    2. A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. Aiba H, et al. DNA Res, 1996 Dec 31. PMID 9097039
    3. Bacterial phenylalanine and phenylacetate catabolic pathway revealed. Teufel R, et al. Proc Natl Acad Sci U S A, 2010 Aug 10. PMID 20660314, Free PMC Article
    4. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858
    5. Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. Ferrández A, et al. J Biol Chem, 1998 Oct 2. PMID 9748275

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-hydroxybutyryl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxybutyryl-CoA dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-hydroxybutyryl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylacetate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-hydroxyadipyl-CoA dehydrogenase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1459054..1460481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415913.1 3-hydroxyadipyl-CoA dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415913.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X3JGB1
      Conserved Domains (1) summary
      TIGR02279
      Location:1 → 475
      PaaC-3OHAcCoADH; 3-hydroxyacyl-CoA dehydrogenase PaaC
    Nucleotide Protein
    Heading Accession and Version

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